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Interventional sialendoscopy for radioiodine-induced sialadenitis: quo vadis?

Salivary gland toxicity is a common adverse effect of radioactive iodine ((131)I) for the treatment of thyroid cancers with a prevalence ranging from 2% to 67% of the (131)I exposed population. Recently, sialendoscopy has been introduced as an attractive diagnostic and therapeutic tool for managemen...

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Autores principales: Canzi, P., Cacciola, S., Capaccio, P., Pagella, F., Occhini, A., Pignataro, L., Benazzo, M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Pacini Editore SRL 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5463524/
https://www.ncbi.nlm.nih.gov/pubmed/28516979
http://dx.doi.org/10.14639/0392-100X-1606
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author Canzi, P.
Cacciola, S.
Capaccio, P.
Pagella, F.
Occhini, A.
Pignataro, L.
Benazzo, M.
author_facet Canzi, P.
Cacciola, S.
Capaccio, P.
Pagella, F.
Occhini, A.
Pignataro, L.
Benazzo, M.
author_sort Canzi, P.
collection PubMed
description Salivary gland toxicity is a common adverse effect of radioactive iodine ((131)I) for the treatment of thyroid cancers with a prevalence ranging from 2% to 67% of the (131)I exposed population. Recently, sialendoscopy has been introduced as an attractive diagnostic and therapeutic tool for management of patients with radioiodine-induced sialadenitis that is unresponsive to standard medical treatments. The objective of the current review was to assess the impact of this procedure on outcomes in patients suffering from radioiodine sialadenitis. Overall, eight studies were included and 122 patients underwent 264 sialendoscopic procedures. Duct stenosis and mucous plugs were observed in 85.7% of endoscopic findings, supporting the role of ductal obstruction in the pathophysiology of radioiodine sialadenitis. In total, 89.3% of patients experienced complete or partial resolution of sialadenitis recurrences without any major adverse events, and parotidectomy was advocated in only 1 case. However, outcomes mainly concerned subjective reports and only two clinical experiences evaluated objective measurement with dissimilar results. Limited to few studies, xerostomia and obstructive symptoms responded differently after sialendoscopy. The optimal timing of salivary gland videoendoscopy needs to be further analysed in order to define the best management of radioiodine-induced obstructive sialadenitis.
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spelling pubmed-54635242017-06-14 Interventional sialendoscopy for radioiodine-induced sialadenitis: quo vadis? Canzi, P. Cacciola, S. Capaccio, P. Pagella, F. Occhini, A. Pignataro, L. Benazzo, M. Acta Otorhinolaryngol Ital Review Salivary gland toxicity is a common adverse effect of radioactive iodine ((131)I) for the treatment of thyroid cancers with a prevalence ranging from 2% to 67% of the (131)I exposed population. Recently, sialendoscopy has been introduced as an attractive diagnostic and therapeutic tool for management of patients with radioiodine-induced sialadenitis that is unresponsive to standard medical treatments. The objective of the current review was to assess the impact of this procedure on outcomes in patients suffering from radioiodine sialadenitis. Overall, eight studies were included and 122 patients underwent 264 sialendoscopic procedures. Duct stenosis and mucous plugs were observed in 85.7% of endoscopic findings, supporting the role of ductal obstruction in the pathophysiology of radioiodine sialadenitis. In total, 89.3% of patients experienced complete or partial resolution of sialadenitis recurrences without any major adverse events, and parotidectomy was advocated in only 1 case. However, outcomes mainly concerned subjective reports and only two clinical experiences evaluated objective measurement with dissimilar results. Limited to few studies, xerostomia and obstructive symptoms responded differently after sialendoscopy. The optimal timing of salivary gland videoendoscopy needs to be further analysed in order to define the best management of radioiodine-induced obstructive sialadenitis. Pacini Editore SRL 2017-04 /pmc/articles/PMC5463524/ /pubmed/28516979 http://dx.doi.org/10.14639/0392-100X-1606 Text en © Copyright by Società Italiana di Otorinolaringologia e Chirurgia Cervico-Facciale, Rome, Italy http://creativecommons.org/licenses/by-nc-nd/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivatives License, which permits for noncommercial use, distribution, and reproduction in any digital medium, provided the original work is properly cited and is not altered in any way. For details, please refer to http://creativecommons.org/licenses/by-nc-nd/3.0/
spellingShingle Review
Canzi, P.
Cacciola, S.
Capaccio, P.
Pagella, F.
Occhini, A.
Pignataro, L.
Benazzo, M.
Interventional sialendoscopy for radioiodine-induced sialadenitis: quo vadis?
title Interventional sialendoscopy for radioiodine-induced sialadenitis: quo vadis?
title_full Interventional sialendoscopy for radioiodine-induced sialadenitis: quo vadis?
title_fullStr Interventional sialendoscopy for radioiodine-induced sialadenitis: quo vadis?
title_full_unstemmed Interventional sialendoscopy for radioiodine-induced sialadenitis: quo vadis?
title_short Interventional sialendoscopy for radioiodine-induced sialadenitis: quo vadis?
title_sort interventional sialendoscopy for radioiodine-induced sialadenitis: quo vadis?
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5463524/
https://www.ncbi.nlm.nih.gov/pubmed/28516979
http://dx.doi.org/10.14639/0392-100X-1606
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