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Is there a role for voltage-gated Na(+) channels in the aggressiveness of breast cancer?

Breast cancer is the most common cancer among women and its metastatic potential is responsible for numerous deaths. Thus, the need to find new targets for improving treatment, and even finding the cure, becomes increasingly greater. Ion channels are known to participate in several physiological fun...

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Autores principales: Rhana, P., Trivelato, R.R., Beirão, P.S.L., Cruz, J.S., Rodrigues, A.L.P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Associação Brasileira de Divulgação Científica 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5463531/
https://www.ncbi.nlm.nih.gov/pubmed/28591378
http://dx.doi.org/10.1590/1414-431X20176011
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author Rhana, P.
Trivelato, R.R.
Beirão, P.S.L.
Cruz, J.S.
Rodrigues, A.L.P.
author_facet Rhana, P.
Trivelato, R.R.
Beirão, P.S.L.
Cruz, J.S.
Rodrigues, A.L.P.
author_sort Rhana, P.
collection PubMed
description Breast cancer is the most common cancer among women and its metastatic potential is responsible for numerous deaths. Thus, the need to find new targets for improving treatment, and even finding the cure, becomes increasingly greater. Ion channels are known to participate in several physiological functions, such as muscle contraction, cell volume regulation, immune response and cell proliferation. In breast cancer, different types of ion channels have been associated with tumorigenesis. Recently, voltage-gated Na(+) channels (VGSC) have been implicated in the processes that lead to increased tumor aggressiveness. To explain this relationship, different theories, associated with pH changes, gene expression and intracellular Ca(2+), have been proposed in an attempt to better understand the role of these ion channels in breast cancer. However, these theories are having difficulty being accepted because most of the findings are contrary to the present scientific knowledge. Several studies have shown that VGSC are related to different types of cancer, making them a promising pharmacological target against this debilitating disease. Molecular biology and cell electrophysiology have been used to look for new forms of treatment aiming to reduce aggressiveness and the disease progress.
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spelling pubmed-54635312017-06-14 Is there a role for voltage-gated Na(+) channels in the aggressiveness of breast cancer? Rhana, P. Trivelato, R.R. Beirão, P.S.L. Cruz, J.S. Rodrigues, A.L.P. Braz J Med Biol Res Reviews Breast cancer is the most common cancer among women and its metastatic potential is responsible for numerous deaths. Thus, the need to find new targets for improving treatment, and even finding the cure, becomes increasingly greater. Ion channels are known to participate in several physiological functions, such as muscle contraction, cell volume regulation, immune response and cell proliferation. In breast cancer, different types of ion channels have been associated with tumorigenesis. Recently, voltage-gated Na(+) channels (VGSC) have been implicated in the processes that lead to increased tumor aggressiveness. To explain this relationship, different theories, associated with pH changes, gene expression and intracellular Ca(2+), have been proposed in an attempt to better understand the role of these ion channels in breast cancer. However, these theories are having difficulty being accepted because most of the findings are contrary to the present scientific knowledge. Several studies have shown that VGSC are related to different types of cancer, making them a promising pharmacological target against this debilitating disease. Molecular biology and cell electrophysiology have been used to look for new forms of treatment aiming to reduce aggressiveness and the disease progress. Associação Brasileira de Divulgação Científica 2017-06-05 /pmc/articles/PMC5463531/ /pubmed/28591378 http://dx.doi.org/10.1590/1414-431X20176011 Text en http://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Reviews
Rhana, P.
Trivelato, R.R.
Beirão, P.S.L.
Cruz, J.S.
Rodrigues, A.L.P.
Is there a role for voltage-gated Na(+) channels in the aggressiveness of breast cancer?
title Is there a role for voltage-gated Na(+) channels in the aggressiveness of breast cancer?
title_full Is there a role for voltage-gated Na(+) channels in the aggressiveness of breast cancer?
title_fullStr Is there a role for voltage-gated Na(+) channels in the aggressiveness of breast cancer?
title_full_unstemmed Is there a role for voltage-gated Na(+) channels in the aggressiveness of breast cancer?
title_short Is there a role for voltage-gated Na(+) channels in the aggressiveness of breast cancer?
title_sort is there a role for voltage-gated na(+) channels in the aggressiveness of breast cancer?
topic Reviews
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5463531/
https://www.ncbi.nlm.nih.gov/pubmed/28591378
http://dx.doi.org/10.1590/1414-431X20176011
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