Presence of t(14;18) translocation in healthy individuals varies according to ethnic background in the Brazilian population

Several groups have demonstrated that healthy individuals can present the t(14;18) translocation. In this report, the presence of the translocation was examined in healthy blood donors in Brazil, a country considered an ethnic melting pot. The translocation was detected by nested PCR in 227 peripher...

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Detalles Bibliográficos
Autores principales: Levy, D., Bertoldi, E.R.M., Ruiz, J.L.M., Pereira, J., Bydlowski, S.P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Associação Brasileira de Divulgação Científica 2017
Materias:
Biomedical Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5463534/
https://www.ncbi.nlm.nih.gov/pubmed/28591381
http://dx.doi.org/10.1590/1414-431X20176172
Descripción
Sumario:Several groups have demonstrated that healthy individuals can present the t(14;18) translocation. In this report, the presence of the translocation was examined in healthy blood donors in Brazil, a country considered an ethnic melting pot. The translocation was detected by nested PCR in 227 peripheral blood samples from individuals with different ethnic backgrounds. The t(14;18) translocation was found in 45 of 85 White individuals (52.94%); in 57 of 72 Black individuals (79.17%); and in 68 of 70 individuals (97.14%) of Japanese-descent. In conclusion, the frequency of the t(14;18) translocation in the Brazilian population varies according to the ethnic background.

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