Presence of t(14;18) translocation in healthy individuals varies according to ethnic background in the Brazilian population

Several groups have demonstrated that healthy individuals can present the t(14;18) translocation. In this report, the presence of the translocation was examined in healthy blood donors in Brazil, a country considered an ethnic melting pot. The translocation was detected by nested PCR in 227 peripher...

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Detalles Bibliográficos
Autores principales: Levy, D., Bertoldi, E.R.M., Ruiz, J.L.M., Pereira, J., Bydlowski, S.P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Associação Brasileira de Divulgação Científica 2017
Materias:
Biomedical Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5463534/
https://www.ncbi.nlm.nih.gov/pubmed/28591381
http://dx.doi.org/10.1590/1414-431X20176172
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author Levy, D.
Bertoldi, E.R.M.
Ruiz, J.L.M.
Pereira, J.
Bydlowski, S.P.
author_facet Levy, D.
Bertoldi, E.R.M.
Ruiz, J.L.M.
Pereira, J.
Bydlowski, S.P.
author_sort Levy, D.
collection PubMed
description Several groups have demonstrated that healthy individuals can present the t(14;18) translocation. In this report, the presence of the translocation was examined in healthy blood donors in Brazil, a country considered an ethnic melting pot. The translocation was detected by nested PCR in 227 peripheral blood samples from individuals with different ethnic backgrounds. The t(14;18) translocation was found in 45 of 85 White individuals (52.94%); in 57 of 72 Black individuals (79.17%); and in 68 of 70 individuals (97.14%) of Japanese-descent. In conclusion, the frequency of the t(14;18) translocation in the Brazilian population varies according to the ethnic background.
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spelling pubmed-54635342017-06-14 Presence of t(14;18) translocation in healthy individuals varies according to ethnic background in the Brazilian population Levy, D. Bertoldi, E.R.M. Ruiz, J.L.M. Pereira, J. Bydlowski, S.P. Braz J Med Biol Res Biomedical Sciences Several groups have demonstrated that healthy individuals can present the t(14;18) translocation. In this report, the presence of the translocation was examined in healthy blood donors in Brazil, a country considered an ethnic melting pot. The translocation was detected by nested PCR in 227 peripheral blood samples from individuals with different ethnic backgrounds. The t(14;18) translocation was found in 45 of 85 White individuals (52.94%); in 57 of 72 Black individuals (79.17%); and in 68 of 70 individuals (97.14%) of Japanese-descent. In conclusion, the frequency of the t(14;18) translocation in the Brazilian population varies according to the ethnic background. Associação Brasileira de Divulgação Científica 2017-06-05 /pmc/articles/PMC5463534/ /pubmed/28591381 http://dx.doi.org/10.1590/1414-431X20176172 Text en http://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Biomedical Sciences
Levy, D.
Bertoldi, E.R.M.
Ruiz, J.L.M.
Pereira, J.
Bydlowski, S.P.
Presence of t(14;18) translocation in healthy individuals varies according to ethnic background in the Brazilian population
title Presence of t(14;18) translocation in healthy individuals varies according to ethnic background in the Brazilian population
title_full Presence of t(14;18) translocation in healthy individuals varies according to ethnic background in the Brazilian population
title_fullStr Presence of t(14;18) translocation in healthy individuals varies according to ethnic background in the Brazilian population
title_full_unstemmed Presence of t(14;18) translocation in healthy individuals varies according to ethnic background in the Brazilian population
title_short Presence of t(14;18) translocation in healthy individuals varies according to ethnic background in the Brazilian population
title_sort presence of t(14;18) translocation in healthy individuals varies according to ethnic background in the brazilian population
topic Biomedical Sciences
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5463534/
https://www.ncbi.nlm.nih.gov/pubmed/28591381
http://dx.doi.org/10.1590/1414-431X20176172
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