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A three‐parameter two‐state model of receptor function that incorporates affinity, efficacy, and signal amplification
A generalized model of receptor function is proposed that relies on the essential assumptions of the minimal two‐state receptor theory (i.e., ligand binding followed by receptor activation), but uses a different parametrization and allows nonlinear response (transduction) for possible signal amplifi...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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John Wiley and Sons Inc.
2017
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5464340/ https://www.ncbi.nlm.nih.gov/pubmed/28603630 http://dx.doi.org/10.1002/prp2.311 |