In vitro metabolism of exemestane by hepatic cytochrome P450s: impact of nonsynonymous polymorphisms on formation of the active metabolite 17β‐dihydroexemestane

Exemestane (EXE) is an endocrine therapy commonly used by postmenopausal women with hormone‐responsive breast cancer due to its potency in inhibiting aromatase‐catalyzed estrogen synthesis. Preliminary in vitro studies sought to identify phase I EXE metabolites and hepatic cytochrome P450s (CYP450s)...

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Detalles Bibliográficos
Autores principales: Peterson, Amity, Xia, Zuping, Chen, Gang, Lazarus, Philip
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2017
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5464343/
https://www.ncbi.nlm.nih.gov/pubmed/28603633
http://dx.doi.org/10.1002/prp2.314

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5464343/
https://www.ncbi.nlm.nih.gov/pubmed/28603633
http://dx.doi.org/10.1002/prp2.314

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