Cargando…

Human Neural Progenitor Transplantation Rescues Behavior and Reduces α‐Synuclein in a Transgenic Model of Dementia with Lewy Bodies

Synucleinopathies are a group of neurodegenerative disorders sharing the common feature of misfolding and accumulation of the presynaptic protein α‐synuclein (α‐syn) into insoluble aggregates. Within this diverse group, Dementia with Lewy Bodies (DLB) is characterized by the aberrant accumulation of...

Descripción completa

Detalles Bibliográficos
Autores principales:	Goldberg, Natalie R.S., Marsh, Samuel E., Ochaba, Joseph, Shelley, Brandon C., Davtyan, Hayk, Thompson, Leslie M., Steffan, Joan S., Svendsen, Clive N., Blurton‐Jones, Mathew
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2017
Materias:	Translational Research Articles and Reviews
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5464354/ https://www.ncbi.nlm.nih.gov/pubmed/28225193 http://dx.doi.org/10.1002/sctm.16-0362

Ejemplares similares

Neural Stem Cells Rescue Cognitive and Motor Dysfunction in a Transgenic Model of Dementia with Lewy Bodies through a BDNF-Dependent Mechanism
por: Goldberg, Natalie R.S., et al.
Publicado: (2015)

Examining the mechanisms that link β-amyloid and α-synuclein pathologies
por: Marsh, Samuel E, et al.
Publicado: (2012)

A Combination of Distinct Vascular Stem/Progenitor Cells for Neovascularization and Ischemic Rescue
por: Zhao, Liming, et al.
Publicado: (2023)

Network dysfunction in α‐synuclein transgenic mice and human Lewy body dementia
por: Morris, Meaghan, et al.
Publicado: (2015)

CRISPR generation of CSF1R-G795A human microglia for robust microglia replacement in a chimeric mouse model
por: Chadarevian, Jean Paul, et al.
Publicado: (2023)

Integrated analysis of genetic, behavioral, and biochemical data implicates neural stem cell-induced changes in immunity, neurotransmission and mitochondrial function in Dementia with Lewy Body mice
por: Lakatos, Anita, et al.
Publicado: (2017)

Immunogenicity of MultiTEP-Platform-Based Recombinant Protein Vaccine, PV-1950R, Targeting Three B-Cell Antigenic Determinants of Pathological α-Synuclein
por: Zagorski, Karen, et al.
Publicado: (2022)

Passive Immunization Reduces Behavioral and Neuropathological Deficits in an Alpha-Synuclein Transgenic Model of Lewy Body Disease
por: Masliah, Eliezer, et al.
Publicado: (2011)

Neuroinflammation is associated with infiltration of T cells in Lewy body disease and α-synuclein transgenic models
por: Iba, Michiyo, et al.
Publicado: (2020)

Development and validation of a simplified method to generate human microglia from pluripotent stem cells
por: McQuade, Amanda, et al.
Publicado: (2018)

Efficacy and immunogenicity of MultiTEP-based DNA vaccines targeting human α-synuclein: prelude for IND enabling studies
por: Kim, Changyoun, et al.
Publicado: (2022)

Author Correction: Efficacy and immunogenicity of MultiTEP-based DNA vaccines targeting human α-synuclein: prelude for IND enabling studies
por: Kim, Changyoun, et al.
Publicado: (2023)

CSPα reduces aggregates and rescues striatal dopamine release in α-synuclein transgenic mice
por: Caló, Laura, et al.
Publicado: (2021)

Alpha-synuclein biology in Lewy body diseases
por: Kim, Woojin Scott, et al.
Publicado: (2014)

Early manifestation of depressive‐like behavior in transgenic mice that express dementia with Lewy body‐linked mutant β‐synuclein
por: Fujita, Masayo, et al.
Publicado: (2018)

Ferumoxytol Labeling of Human Neural Progenitor Cells for Diagnostic Cellular Tracking in the Porcine Spinal Cord with Magnetic Resonance Imaging
por: Lamanna, Jason J., et al.
Publicado: (2016)

Malaria Control with Transgenic Mosquitoes
por: Marshall, John M, et al.
Publicado: (2009)

Glial cell line-derived neurotrophic factor-secreting human neural progenitors show long-term survival, maturation into astrocytes, and no tumor formation following transplantation into the spinal cord of immunocompromised rats
por: Gowing, Geneviève, et al.
Publicado: (2014)

Chromosome 7 and 19 Trisomy in Cultured Human Neural Progenitor Cells
por: Sareen, Dhruv, et al.
Publicado: (2009)

Induction of Mesoderm and Neural Crest-Derived Pericytes from Human Pluripotent Stem Cells to Study Blood-Brain Barrier Interactions
por: Faal, Tannaz, et al.
Publicado: (2019)

Drug development challenges in nontuberculous mycobacterial lung disease: TB to the rescue
por: Dartois, Véronique, et al.
Publicado: (2022)

Transgenic pigs to the rescue
por: Petersen, Björn
Publicado: (2018)

GDNF Secreting Human Neural Progenitor Cells Protect Dying Motor Neurons, but Not Their Projection to Muscle, in a Rat Model of Familial ALS
por: Suzuki, Masatoshi, et al.
Publicado: (2007)

Human Neural Stem Cell Transplantation Rescues Functional Deficits in R6/2 and Q140 Huntington's Disease Mice
por: Reidling, Jack C., et al.
Publicado: (2017)

Correction of anaemia through the use of darbepoetin alfa improves chemotherapeutic outcome in a murine model of Lewis lung carcinoma
por: Shannon, A M, et al.
Publicado: (2005)

Longitudinal live imaging of retinal α-synuclein::GFP deposits in a transgenic mouse model of Parkinson’s Disease/Dementia with Lewy Bodies
por: Price, Diana L., et al.
Publicado: (2016)

Possible Role of Amyloidogenic Evolvability in Dementia with Lewy Bodies: Insights from Transgenic Mice Expressing P123H β-Synuclein
por: Fujita, Masayo, et al.
Publicado: (2020)

Role of Alterations in Protein Kinase p38γ in the Pathogenesis of the Synaptic Pathology in Dementia With Lewy Bodies and α-Synuclein Transgenic Models
por: Iba, Michiyo, et al.
Publicado: (2020)

Targeted proteolytic products of τ and α-synuclein in neurodegeneration
por: Xia, Yuxing, et al.
Publicado: (2021)

α-Synuclein as CSF and Blood Biomarker of Dementia with Lewy Bodies
por: Kasuga, Kensaku, et al.
Publicado: (2012)

Modeling Sporadic Alzheimer's Disease in Human Brain Organoids under Serum Exposure
por: Chen, Xianwei, et al.
Publicado: (2021)

Humanized monoclonal antibody armanezumab specific to N-terminus of pathological tau: characterization and therapeutic potency
por: Agadjanyan, Michael G., et al.
Publicado: (2017)

α-Synuclein aggregates amplified from patient-derived Lewy bodies recapitulate Lewy body diseases in mice
por: Uemura, Norihito, et al.
Publicado: (2023)

Structures of α-synuclein filaments from human brains with Lewy pathology
por: Yang, Yang, et al.
Publicado: (2022)

Distinct biological activity of Lewy body α-Synuclein strain in mice
por: Uemura, Norihito, et al.
Publicado: (2023)

RT-QuIC-based detection of alpha-synuclein seeding activity in brains of dementia with Lewy Body patients and of a transgenic mouse model of synucleinopathy
por: Han, Jung-Youn, et al.
Publicado: (2020)

Investigating the Pathogenic Interplay of Alpha-Synuclein, Tau, and Amyloid Beta in Lewy Body Dementia: Insights from Viral-Mediated Overexpression in Transgenic Mouse Models
por: Lim, Melina J., et al.
Publicado: (2023)

HuCNS-SC Human NSCs Fail to Differentiate, Form Ectopic Clusters, and Provide No Cognitive Benefits in a Transgenic Model of Alzheimer's Disease
por: Marsh, Samuel E., et al.
Publicado: (2017)

Dexrazoxane-afforded protection against chronic anthracycline cardiotoxicity in vivo: effective rescue of cardiomyocytes from apoptotic cell death
por: Popelová, O, et al.
Publicado: (2009)

Everolimus Rescues the Phenotype of Elastin Insufficiency in Patient Induced Pluripotent Stem Cell–Derived Vascular Smooth Muscle Cells
por: Kinnear, Caroline, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_cbhcrephr5o1rs7o345eim098b