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Synthesis and pharmacological evaluation of novel selective MOR agonist 6β-pyridinyl amidomorphines exhibiting long-lasting antinociception

It was previously reported that 6β-aminomorphinan derivatives show high affinity for opiate receptors. Novel 6β-heteroarylamidomorphinanes were designed based on the MOR selective antagonist NAP. The 6β-aminomorphinanes were prepared by stereoselective Mitsunobu reaction and subsequently acylated wi...

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Detalles Bibliográficos
Autores principales:	Urai, Ákos, Váradi, András, Szőcs, Levente, Komjáti, Balázs, Le Rouzic, Valerie, Hunkele, Amanda, Pasternak, Gavril W., Majumdar, Susruta, Hosztafi, Sándor
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Royal Society of Chemistry 2016
Materias:	Chemistry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5464418/ https://www.ncbi.nlm.nih.gov/pubmed/28603600 http://dx.doi.org/10.1039/c6md00450d

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