Cargando…

The Meningioma 1 (MN1) Gene is an Independent Poor Prognostic Factor in Adult Egyptian Acute Myeloid Leukemia Patients

AIM: To determine the prognostic importance of meningioma 1 (MN1) gene expression levels in the context of other predictive markers for acute myeloid leukemia (AML) cases. METHODS: MN1 expression was measured in 85 newly diagnosed adults younger than 60 years by real-time reverse-transcriptase polym...

Descripción completa

Detalles Bibliográficos
Autores principales: Shafik, Roxan E, Hassan, Naglaa M, Meligui, Yomna M El, Shafik, Hanan E
Formato: Online Artículo Texto
Lenguaje:English
Publicado: West Asia Organization for Cancer Prevention 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5464473/
https://www.ncbi.nlm.nih.gov/pubmed/28440611
http://dx.doi.org/10.22034/APJCP.2017.18.3.609
_version_ 1783242774747807744
author Shafik, Roxan E
Hassan, Naglaa M
Meligui, Yomna M El
Shafik, Hanan E
author_facet Shafik, Roxan E
Hassan, Naglaa M
Meligui, Yomna M El
Shafik, Hanan E
author_sort Shafik, Roxan E
collection PubMed
description AIM: To determine the prognostic importance of meningioma 1 (MN1) gene expression levels in the context of other predictive markers for acute myeloid leukemia (AML) cases. METHODS: MN1 expression was measured in 85 newly diagnosed adults younger than 60 years by real-time reverse-transcriptase polymerase chain reaction. RESULTS: At diagnosis 67.4% of cases had elevated MN1 expression, this being associated with a worse prognosis, higher incidence of lymphadenopathy and CD34 transcript expression (p=0.02 and <0.001, respectively). No other molecular or clinical characteristics were significantly associated with MN1expression. Patients with high MN1 expression had lower complete response rate at day 15 compared to patients with low MN1 expression (p=0.09) and a significantly higher relapse rate (21.1% versus 7.7%, respectively, p=0.04). Patients with high MN1 expression had shorter TTP compared to those with low expression, p= 0.07. CONCLUSION: MN1 expression may predict outcome in AML patients. The MN1 gene and micro RNA expression suggest a biological feature that could be used as therapeutic targets.
format Online
Article
Text
id pubmed-5464473
institution National Center for Biotechnology Information
language English
publishDate 2017
publisher West Asia Organization for Cancer Prevention
record_format MEDLINE/PubMed
spelling pubmed-54644732017-08-28 The Meningioma 1 (MN1) Gene is an Independent Poor Prognostic Factor in Adult Egyptian Acute Myeloid Leukemia Patients Shafik, Roxan E Hassan, Naglaa M Meligui, Yomna M El Shafik, Hanan E Asian Pac J Cancer Prev Research Article AIM: To determine the prognostic importance of meningioma 1 (MN1) gene expression levels in the context of other predictive markers for acute myeloid leukemia (AML) cases. METHODS: MN1 expression was measured in 85 newly diagnosed adults younger than 60 years by real-time reverse-transcriptase polymerase chain reaction. RESULTS: At diagnosis 67.4% of cases had elevated MN1 expression, this being associated with a worse prognosis, higher incidence of lymphadenopathy and CD34 transcript expression (p=0.02 and <0.001, respectively). No other molecular or clinical characteristics were significantly associated with MN1expression. Patients with high MN1 expression had lower complete response rate at day 15 compared to patients with low MN1 expression (p=0.09) and a significantly higher relapse rate (21.1% versus 7.7%, respectively, p=0.04). Patients with high MN1 expression had shorter TTP compared to those with low expression, p= 0.07. CONCLUSION: MN1 expression may predict outcome in AML patients. The MN1 gene and micro RNA expression suggest a biological feature that could be used as therapeutic targets. West Asia Organization for Cancer Prevention 2017 /pmc/articles/PMC5464473/ /pubmed/28440611 http://dx.doi.org/10.22034/APJCP.2017.18.3.609 Text en Copyright: © Asian Pacific Journal of Cancer Prevention http://creativecommons.org/licenses/BY-SA/4.0 This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License
spellingShingle Research Article
Shafik, Roxan E
Hassan, Naglaa M
Meligui, Yomna M El
Shafik, Hanan E
The Meningioma 1 (MN1) Gene is an Independent Poor Prognostic Factor in Adult Egyptian Acute Myeloid Leukemia Patients
title The Meningioma 1 (MN1) Gene is an Independent Poor Prognostic Factor in Adult Egyptian Acute Myeloid Leukemia Patients
title_full The Meningioma 1 (MN1) Gene is an Independent Poor Prognostic Factor in Adult Egyptian Acute Myeloid Leukemia Patients
title_fullStr The Meningioma 1 (MN1) Gene is an Independent Poor Prognostic Factor in Adult Egyptian Acute Myeloid Leukemia Patients
title_full_unstemmed The Meningioma 1 (MN1) Gene is an Independent Poor Prognostic Factor in Adult Egyptian Acute Myeloid Leukemia Patients
title_short The Meningioma 1 (MN1) Gene is an Independent Poor Prognostic Factor in Adult Egyptian Acute Myeloid Leukemia Patients
title_sort meningioma 1 (mn1) gene is an independent poor prognostic factor in adult egyptian acute myeloid leukemia patients
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5464473/
https://www.ncbi.nlm.nih.gov/pubmed/28440611
http://dx.doi.org/10.22034/APJCP.2017.18.3.609
work_keys_str_mv AT shafikroxane themeningioma1mn1geneisanindependentpoorprognosticfactorinadultegyptianacutemyeloidleukemiapatients
AT hassannaglaam themeningioma1mn1geneisanindependentpoorprognosticfactorinadultegyptianacutemyeloidleukemiapatients
AT meliguiyomnamel themeningioma1mn1geneisanindependentpoorprognosticfactorinadultegyptianacutemyeloidleukemiapatients
AT shafikhanane themeningioma1mn1geneisanindependentpoorprognosticfactorinadultegyptianacutemyeloidleukemiapatients
AT shafikroxane meningioma1mn1geneisanindependentpoorprognosticfactorinadultegyptianacutemyeloidleukemiapatients
AT hassannaglaam meningioma1mn1geneisanindependentpoorprognosticfactorinadultegyptianacutemyeloidleukemiapatients
AT meliguiyomnamel meningioma1mn1geneisanindependentpoorprognosticfactorinadultegyptianacutemyeloidleukemiapatients
AT shafikhanane meningioma1mn1geneisanindependentpoorprognosticfactorinadultegyptianacutemyeloidleukemiapatients