Cargando…
The Meningioma 1 (MN1) Gene is an Independent Poor Prognostic Factor in Adult Egyptian Acute Myeloid Leukemia Patients
AIM: To determine the prognostic importance of meningioma 1 (MN1) gene expression levels in the context of other predictive markers for acute myeloid leukemia (AML) cases. METHODS: MN1 expression was measured in 85 newly diagnosed adults younger than 60 years by real-time reverse-transcriptase polym...
Autores principales: | , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
West Asia Organization for Cancer Prevention
2017
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5464473/ https://www.ncbi.nlm.nih.gov/pubmed/28440611 http://dx.doi.org/10.22034/APJCP.2017.18.3.609 |
_version_ | 1783242774747807744 |
---|---|
author | Shafik, Roxan E Hassan, Naglaa M Meligui, Yomna M El Shafik, Hanan E |
author_facet | Shafik, Roxan E Hassan, Naglaa M Meligui, Yomna M El Shafik, Hanan E |
author_sort | Shafik, Roxan E |
collection | PubMed |
description | AIM: To determine the prognostic importance of meningioma 1 (MN1) gene expression levels in the context of other predictive markers for acute myeloid leukemia (AML) cases. METHODS: MN1 expression was measured in 85 newly diagnosed adults younger than 60 years by real-time reverse-transcriptase polymerase chain reaction. RESULTS: At diagnosis 67.4% of cases had elevated MN1 expression, this being associated with a worse prognosis, higher incidence of lymphadenopathy and CD34 transcript expression (p=0.02 and <0.001, respectively). No other molecular or clinical characteristics were significantly associated with MN1expression. Patients with high MN1 expression had lower complete response rate at day 15 compared to patients with low MN1 expression (p=0.09) and a significantly higher relapse rate (21.1% versus 7.7%, respectively, p=0.04). Patients with high MN1 expression had shorter TTP compared to those with low expression, p= 0.07. CONCLUSION: MN1 expression may predict outcome in AML patients. The MN1 gene and micro RNA expression suggest a biological feature that could be used as therapeutic targets. |
format | Online Article Text |
id | pubmed-5464473 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | West Asia Organization for Cancer Prevention |
record_format | MEDLINE/PubMed |
spelling | pubmed-54644732017-08-28 The Meningioma 1 (MN1) Gene is an Independent Poor Prognostic Factor in Adult Egyptian Acute Myeloid Leukemia Patients Shafik, Roxan E Hassan, Naglaa M Meligui, Yomna M El Shafik, Hanan E Asian Pac J Cancer Prev Research Article AIM: To determine the prognostic importance of meningioma 1 (MN1) gene expression levels in the context of other predictive markers for acute myeloid leukemia (AML) cases. METHODS: MN1 expression was measured in 85 newly diagnosed adults younger than 60 years by real-time reverse-transcriptase polymerase chain reaction. RESULTS: At diagnosis 67.4% of cases had elevated MN1 expression, this being associated with a worse prognosis, higher incidence of lymphadenopathy and CD34 transcript expression (p=0.02 and <0.001, respectively). No other molecular or clinical characteristics were significantly associated with MN1expression. Patients with high MN1 expression had lower complete response rate at day 15 compared to patients with low MN1 expression (p=0.09) and a significantly higher relapse rate (21.1% versus 7.7%, respectively, p=0.04). Patients with high MN1 expression had shorter TTP compared to those with low expression, p= 0.07. CONCLUSION: MN1 expression may predict outcome in AML patients. The MN1 gene and micro RNA expression suggest a biological feature that could be used as therapeutic targets. West Asia Organization for Cancer Prevention 2017 /pmc/articles/PMC5464473/ /pubmed/28440611 http://dx.doi.org/10.22034/APJCP.2017.18.3.609 Text en Copyright: © Asian Pacific Journal of Cancer Prevention http://creativecommons.org/licenses/BY-SA/4.0 This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License |
spellingShingle | Research Article Shafik, Roxan E Hassan, Naglaa M Meligui, Yomna M El Shafik, Hanan E The Meningioma 1 (MN1) Gene is an Independent Poor Prognostic Factor in Adult Egyptian Acute Myeloid Leukemia Patients |
title | The Meningioma 1 (MN1) Gene is an Independent Poor Prognostic Factor in Adult Egyptian Acute Myeloid Leukemia Patients |
title_full | The Meningioma 1 (MN1) Gene is an Independent Poor Prognostic Factor in Adult Egyptian Acute Myeloid Leukemia Patients |
title_fullStr | The Meningioma 1 (MN1) Gene is an Independent Poor Prognostic Factor in Adult Egyptian Acute Myeloid Leukemia Patients |
title_full_unstemmed | The Meningioma 1 (MN1) Gene is an Independent Poor Prognostic Factor in Adult Egyptian Acute Myeloid Leukemia Patients |
title_short | The Meningioma 1 (MN1) Gene is an Independent Poor Prognostic Factor in Adult Egyptian Acute Myeloid Leukemia Patients |
title_sort | meningioma 1 (mn1) gene is an independent poor prognostic factor in adult egyptian acute myeloid leukemia patients |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5464473/ https://www.ncbi.nlm.nih.gov/pubmed/28440611 http://dx.doi.org/10.22034/APJCP.2017.18.3.609 |
work_keys_str_mv | AT shafikroxane themeningioma1mn1geneisanindependentpoorprognosticfactorinadultegyptianacutemyeloidleukemiapatients AT hassannaglaam themeningioma1mn1geneisanindependentpoorprognosticfactorinadultegyptianacutemyeloidleukemiapatients AT meliguiyomnamel themeningioma1mn1geneisanindependentpoorprognosticfactorinadultegyptianacutemyeloidleukemiapatients AT shafikhanane themeningioma1mn1geneisanindependentpoorprognosticfactorinadultegyptianacutemyeloidleukemiapatients AT shafikroxane meningioma1mn1geneisanindependentpoorprognosticfactorinadultegyptianacutemyeloidleukemiapatients AT hassannaglaam meningioma1mn1geneisanindependentpoorprognosticfactorinadultegyptianacutemyeloidleukemiapatients AT meliguiyomnamel meningioma1mn1geneisanindependentpoorprognosticfactorinadultegyptianacutemyeloidleukemiapatients AT shafikhanane meningioma1mn1geneisanindependentpoorprognosticfactorinadultegyptianacutemyeloidleukemiapatients |