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Noninvasive assessment of respiratory muscle strength and activity in Myotonic dystrophy

OBJECTIVE: To evaluate sensitivity/specificity of the maximum relaxation rate (MRR) of inspiratory muscles, amplitude of electromyographic activity of the sternocleidomastoid (SCM), scalene (SCA), parasternal (2(nd)IS) and rectus abdominis (RA) muscles; lung function and respiratory muscle strength...

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Autores principales: Evangelista, Morgana de Araújo, Dias, Fernando Augusto Lavezzo, Dourado Júnior, Mário Emílio Teixeira, do Nascimento, George Carlos, Sarmento, Antonio, Gualdi, Lucien Peroni, Aliverti, Andrea, Resqueti, Vanessa, Fregonezi, Guilherme Augusto de Freitas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5464542/
https://www.ncbi.nlm.nih.gov/pubmed/28594857
http://dx.doi.org/10.1371/journal.pone.0177318
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author Evangelista, Morgana de Araújo
Dias, Fernando Augusto Lavezzo
Dourado Júnior, Mário Emílio Teixeira
do Nascimento, George Carlos
Sarmento, Antonio
Gualdi, Lucien Peroni
Aliverti, Andrea
Resqueti, Vanessa
Fregonezi, Guilherme Augusto de Freitas
author_facet Evangelista, Morgana de Araújo
Dias, Fernando Augusto Lavezzo
Dourado Júnior, Mário Emílio Teixeira
do Nascimento, George Carlos
Sarmento, Antonio
Gualdi, Lucien Peroni
Aliverti, Andrea
Resqueti, Vanessa
Fregonezi, Guilherme Augusto de Freitas
author_sort Evangelista, Morgana de Araújo
collection PubMed
description OBJECTIVE: To evaluate sensitivity/specificity of the maximum relaxation rate (MRR) of inspiratory muscles, amplitude of electromyographic activity of the sternocleidomastoid (SCM), scalene (SCA), parasternal (2(nd)IS) and rectus abdominis (RA) muscles; lung function and respiratory muscle strength in subjects with Myotonic dystrophy type 1 (DM(1)) compared with healthy subjects. DESIGN AND METHODS: Quasi-experimental observational study with control group. MRR of inspiratory muscles, lung function and amplitude of the electromyographic activity of SCM, SCA, 2(nd)IS and RA muscles during maximum inspiratory pressure (PImax), maximum expiratory pressure (PEmax) and sniff nasal inspiratory pressure (SNIP) tests were assessed in eighteen DM(1) subjects and eleven healthy. RESULTS: MRR was lower in DM(1) group compared to healthy (P = 0.001) and was considered sensitive and specific to identify disease in DM(1) and discard it in controls, as well as SNIP% (P = 0.0026), PImax% (P = 0.0077) and PEmax% (P = 0.0002). Contraction time of SCM and SCA was higher in DM(1) compared to controls, respectively, during PImax (P = 0.023 and P = 0.017) and SNIP (P = 0.015 and P = .0004). The DM(1) group showed lower PImax (P = .0006), PEmax (P = 0.0002), SNIP (P = 0.0014), and higher electromyographic activity of the SCM (P = 0.002) and SCA (P = 0.004) at rest; of 2(nd)IS (P = 0.003) during PEmax and of SCM (P = 0.02) and SCA (P = 0.03) during SNIP test. CONCLUSIONS: MD(1) subjects presented restrictive pattern, reduced respiratory muscle strength, muscular electrical activity and MRR when compared to higher compared to controls. In addition, the lower MRR found in MD(1) subjects showed to be reliable to sensitivity and specificity in identifying the delayed relaxation of respiratory muscles.
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spelling pubmed-54645422017-06-22 Noninvasive assessment of respiratory muscle strength and activity in Myotonic dystrophy Evangelista, Morgana de Araújo Dias, Fernando Augusto Lavezzo Dourado Júnior, Mário Emílio Teixeira do Nascimento, George Carlos Sarmento, Antonio Gualdi, Lucien Peroni Aliverti, Andrea Resqueti, Vanessa Fregonezi, Guilherme Augusto de Freitas PLoS One Research Article OBJECTIVE: To evaluate sensitivity/specificity of the maximum relaxation rate (MRR) of inspiratory muscles, amplitude of electromyographic activity of the sternocleidomastoid (SCM), scalene (SCA), parasternal (2(nd)IS) and rectus abdominis (RA) muscles; lung function and respiratory muscle strength in subjects with Myotonic dystrophy type 1 (DM(1)) compared with healthy subjects. DESIGN AND METHODS: Quasi-experimental observational study with control group. MRR of inspiratory muscles, lung function and amplitude of the electromyographic activity of SCM, SCA, 2(nd)IS and RA muscles during maximum inspiratory pressure (PImax), maximum expiratory pressure (PEmax) and sniff nasal inspiratory pressure (SNIP) tests were assessed in eighteen DM(1) subjects and eleven healthy. RESULTS: MRR was lower in DM(1) group compared to healthy (P = 0.001) and was considered sensitive and specific to identify disease in DM(1) and discard it in controls, as well as SNIP% (P = 0.0026), PImax% (P = 0.0077) and PEmax% (P = 0.0002). Contraction time of SCM and SCA was higher in DM(1) compared to controls, respectively, during PImax (P = 0.023 and P = 0.017) and SNIP (P = 0.015 and P = .0004). The DM(1) group showed lower PImax (P = .0006), PEmax (P = 0.0002), SNIP (P = 0.0014), and higher electromyographic activity of the SCM (P = 0.002) and SCA (P = 0.004) at rest; of 2(nd)IS (P = 0.003) during PEmax and of SCM (P = 0.02) and SCA (P = 0.03) during SNIP test. CONCLUSIONS: MD(1) subjects presented restrictive pattern, reduced respiratory muscle strength, muscular electrical activity and MRR when compared to higher compared to controls. In addition, the lower MRR found in MD(1) subjects showed to be reliable to sensitivity and specificity in identifying the delayed relaxation of respiratory muscles. Public Library of Science 2017-06-08 /pmc/articles/PMC5464542/ /pubmed/28594857 http://dx.doi.org/10.1371/journal.pone.0177318 Text en © 2017 Evangelista et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Evangelista, Morgana de Araújo
Dias, Fernando Augusto Lavezzo
Dourado Júnior, Mário Emílio Teixeira
do Nascimento, George Carlos
Sarmento, Antonio
Gualdi, Lucien Peroni
Aliverti, Andrea
Resqueti, Vanessa
Fregonezi, Guilherme Augusto de Freitas
Noninvasive assessment of respiratory muscle strength and activity in Myotonic dystrophy
title Noninvasive assessment of respiratory muscle strength and activity in Myotonic dystrophy
title_full Noninvasive assessment of respiratory muscle strength and activity in Myotonic dystrophy
title_fullStr Noninvasive assessment of respiratory muscle strength and activity in Myotonic dystrophy
title_full_unstemmed Noninvasive assessment of respiratory muscle strength and activity in Myotonic dystrophy
title_short Noninvasive assessment of respiratory muscle strength and activity in Myotonic dystrophy
title_sort noninvasive assessment of respiratory muscle strength and activity in myotonic dystrophy
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5464542/
https://www.ncbi.nlm.nih.gov/pubmed/28594857
http://dx.doi.org/10.1371/journal.pone.0177318
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