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The monoclonal S9.6 antibody exhibits highly variable binding affinities towards different R-loop sequences

The monoclonal antibody S9.6 is a widely-used tool to purify, analyse and quantify R-loop structures in cells. A previous study using the surface plasmon resonance technology and a single-chain variable fragment (scFv) of S9.6 showed high affinity (0.6 nM) for DNA—RNA and also a high affinity (2.7 n...

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Detalles Bibliográficos
Autores principales:	König, Fabian, Schubert, Thomas, Längst, Gernot
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2017
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5464589/ https://www.ncbi.nlm.nih.gov/pubmed/28594954 http://dx.doi.org/10.1371/journal.pone.0178875

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