Cargando…

Design of short peptides to block BTLA/HVEM interactions for promoting anticancer T-cell responses

Antibody based immune-checkpoint blockade therapy is a major breakthrough in oncology, leading to clinical benefit for cancer patients. Among the growing family of inhibitory receptors, the B and T lymphocyte attenuator (BTLA), which interacts with herpes virus entry mediator (HVEM), is a promising...

Descripción completa

Detalles Bibliográficos
Autores principales:	Spodzieja, Marta, Lach, Sławomir, Iwaszkiewicz, Justyna, Cesson, Valérie, Kalejta, Katarzyna, Olive, Daniel, Michielin, Olivier, Speiser, Daniel E., Zoete, Vincent, Derré, Laurent, Rodziewicz-Motowidło, Sylwia
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2017
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5464627/ https://www.ncbi.nlm.nih.gov/pubmed/28594868 http://dx.doi.org/10.1371/journal.pone.0179201

Ejemplares similares

Disulfide-Linked Peptides for Blocking BTLA/HVEM Binding
por: Spodzieja, Marta, et al.
Publicado: (2020)

Fragments of gD Protein as Inhibitors of BTLA/HVEM Complex Formation - Design, Synthesis, and Cellular Studies
por: Kuncewicz, Katarzyna, et al.
Publicado: (2020)

A structural model of the immune checkpoint CD160–HVEM complex derived from HDX-mass spectrometry and molecular modeling
por: Kuncewicz, Katarzyna, et al.
Publicado: (2019)

BTLA inhibition has a dominant role in the cis-complex of BTLA and HVEM
por: Battin, Claire, et al.
Publicado: (2022)

BTLA-HVEM Couple in Health and Diseases: Insights for Immunotherapy in Lung Cancer
por: Demerlé, Clemence, et al.
Publicado: (2021)

A crucial role for HVEM and BTLA in preventing intestinal inflammation
por: Steinberg, Marcos W., et al.
Publicado: (2008)

Anti-HVEM mAb therapy improves antitumoral immunity both in vitro and in vivo, in a novel transgenic mouse model expressing human HVEM and BTLA molecules challenged with HVEM expressing tumors
por: Demerlé, Clémence, et al.
Publicado: (2023)

Increased BTLA and HVEM in gastric cancer are associated with progression and poor prognosis
por: Lan, Xiuwen, et al.
Publicado: (2017)

Attenuation of the BTLA/HVEM Regulatory Network in the Circulation in Primary Sjögren’s Syndrome
por: Small, Annabelle, et al.
Publicado: (2022)

The BTLA–HVEM–CD5 Immunoregulatory Axis–An Instructive Mechanism Governing pTreg Cell Differentiation
por: Bourque, Jessica, et al.
Publicado: (2019)

BTLA/HVEM Signaling: Milestones in Research and Role in Chronic Hepatitis B Virus Infection
por: Yu, Xueping, et al.
Publicado: (2019)

HVEM structures and mutants reveal distinct functions of binding to LIGHT and BTLA/CD160
por: Liu, Weifeng, et al.
Publicado: (2021)

The Expression of LIGHT Was Increased and the Expression of HVEM and BTLA Were Decreased in the T Cells of Patients with Rheumatoid Arthritis
por: Yang, Bin, et al.
Publicado: (2016)

BTLA/HVEM Axis Induces NK Cell Immunosuppression and Poor Outcome in Chronic Lymphocytic Leukemia
por: Sordo-Bahamonde, Christian, et al.
Publicado: (2021)

Correction: Anti-HVEM mAb therapy improves antitumoral immunity both in vitro and in vivo, in a novel transgenic mouse model expressing human HVEM and BTLA molecules challenged with HVEM expressing tumors
Publicado: (2023)

CD8 T Cell Memory to a Viral Pathogen Requires Trans Cosignaling between HVEM and BTLA
por: Flynn, Rachel, et al.
Publicado: (2013)

Correction: The Expression of LIGHT Was Increased and the Expression of HVEM and BTLA Were Decreased in the T Cells of Patients with Rheumatoid Arthritis
por: Yang, Bin, et al.
Publicado: (2017)

The HVEM-BTLA Immune Checkpoint Restrains Murine Chronic Cholestatic Liver Injury by Regulating the Gut Microbiota
por: Kou, Yanbo, et al.
Publicado: (2022)

Spectroscopic Methods Used in Implant Material Studies
por: Lach, Sławomir, et al.
Publicado: (2020)

The Intrahepatic Expression and Distribution of BTLA and its Ligand HVEM in patients with HBV-related acute-on-chronic liver failure
por: Xu, Huan, et al.
Publicado: (2012)

Distinct Changes of BTLA and HVEM Expressions in Circulating CD4(+) and CD8(+) T Cells in Hepatocellular Carcinoma Patients
por: Liu, Jiayu, et al.
Publicado: (2018)

Allosteric regulation of binding specificity of HVEM for CD160 and BTLA ligands upon G89F mutation
por: Shrestha, Rojan, et al.
Publicado: (2021)

BTLA Interaction with HVEM Expressed on CD8(+) T Cells Promotes Survival and Memory Generation in Response to a Bacterial Infection
por: Steinberg, Marcos W., et al.
Publicado: (2013)

Associations between HVEM/LIGHT/BTLA/CD160 polymorphisms and the occurrence of antibody-mediate rejection in renal transplant recipients
por: Wang, Zijie, et al.
Publicado: (2017)

The HVEM-BTLA Axis Restrains T Cell Help to Germinal Center B Cells and Functions as a Cell-Extrinsic Suppressor in Lymphomagenesis
por: Mintz, Michelle A., et al.
Publicado: (2019)

Blockade of HVEM for Prostate Cancer Immunotherapy in Humanized Mice
por: Aubert, Nicolas, et al.
Publicado: (2021)

Lymphocyte HVEM/BTLA co-expression after critical illness demonstrates severity indiscriminate upregulation, impacting critical illness-induced immunosuppression
por: Wakeley, Michelle E., et al.
Publicado: (2023)

Beyond the anti-PD-1/PD-L1 era: promising role of the BTLA/HVEM axis as a future target for cancer immunotherapy
por: Sordo-Bahamonde, Christian, et al.
Publicado: (2023)

HVEM Signalling Promotes Colitis
por: Schaer, Corinne, et al.
Publicado: (2011)

BTLA, a key regulator of Vγ9Vδ2 T-cell proliferation
por: Gertner-Dardenne, Julie, et al.
Publicado: (2013)

Prediction of Aggregation of Biologically-Active Peptides with the UNRES Coarse-Grained Model
por: Biskupek, Iga, et al.
Publicado: (2022)

LIGHT–HVEM signaling in keratinocytes controls development of dermatitis
por: Herro, Rana, et al.
Publicado: (2018)

Antibacterial Peptides in Dermatology–Strategies for Evaluation of Allergic Potential
por: Deptuła, Milena, et al.
Publicado: (2018)

Roles of BTLA in Immunity and Immune Disorders
por: Ning, Zhaochen, et al.
Publicado: (2021)

Influence of point mutations on the stability, dimerization, and oligomerization of human cystatin C and its L68Q variant
por: Szymańska, Aneta, et al.
Publicado: (2012)

The Influence of the Mixed DPC:SDS Micelle on the Structure and Oligomerization Process of the Human Cystatin C
por: Jurczak, Przemyslaw, et al.
Publicado: (2020)

Virtual Evolution of HVEM Segment for Checkpoint Inhibitor Discovery
por: Yu, Mingjia, et al.
Publicado: (2021)

Mutations in the palm domain disrupt modulation of acid-sensing ion channel 1a currents by neuropeptides
por: Bargeton, Benoîte, et al.
Publicado: (2019)

Modulation of LIGHT-HVEM Costimulation Prolongs Cardiac Allograft Survival
por: Ye, Qunrui, et al.
Publicado: (2002)

Nectin-1 and HVEM: cellular receptors for HSV-1 in skin
por: Knebel-Mörsdorf, Dagmar
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_dke130enau6774ju4mhgbopti9