Zoledronate suppressed angiogenesis and osteogenesis by inhibiting osteoclasts formation and secretion of PDGF-BB

PURPOSE: Bisphosphonates related osteonecrosis of jaw (BRONJ) is a severe complication of systemic BPs administration, the mechanism of which is still unclarified. Recently, platelet-derived growth factor-BB (PDGF-BB) secreted by preosteoclasts was reported to promote angiogenesis and osteogenesis....

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Detalles Bibliográficos
Autores principales: Gao, Si-yong, Zheng, Guang-sen, Wang, Lin, Liang, Yu-jie, Zhang, Si-en, Lao, Xiao-mei, Li, Kan, Liao, Gui-qing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5464661/
https://www.ncbi.nlm.nih.gov/pubmed/28594896
http://dx.doi.org/10.1371/journal.pone.0179248

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5464661/
https://www.ncbi.nlm.nih.gov/pubmed/28594896
http://dx.doi.org/10.1371/journal.pone.0179248

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