Cargando…

Caspase-8 contributes to angiogenesis and chemotherapy resistance in glioblastoma

Caspase-8 is a key player in extrinsic apoptosis and its activity is often downregulated in cancer. However, human Caspase-8 expression is retained in some tumors, including glioblastoma (GBM), suggesting that it may support cancer growth in these contexts. GBM, the most aggressive of the gliomas, i...

Descripción completa

Detalles Bibliográficos
Autores principales:	Fianco, Giulia, Mongiardi, Maria Patrizia, Levi, Andrea, De Luca, Teresa, Desideri, Marianna, Trisciuoglio, Daniela, Del Bufalo, Donatella, Cinà, Irene, Di Benedetto, Anna, Mottolese, Marcella, Gentile, Antonietta, Centonze, Diego, Ferrè, Fabrizio, Barilà, Daniela
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2017
Materias:	Cancer Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5464770/ https://www.ncbi.nlm.nih.gov/pubmed/28594322 http://dx.doi.org/10.7554/eLife.22593

Ejemplares similares

Caspase-8: A Novel Target to Overcome Resistance to Chemotherapy in Glioblastoma
por: Fianco, Giulia, et al.
Publicado: (2018)

ATM kinase activity modulates ITCH E3-ubiquitin ligase activity
por: Santini, Simonetta, et al.
Publicado: (2013)

Bcl-2 Regulates HIF-1α Protein Stabilization in Hypoxic Melanoma Cells via the Molecular Chaperone HSP90
por: Trisciuoglio, Daniela, et al.
Publicado: (2010)

Tug of War between Survival and Death: Exploring ATM Function in Cancer
por: Stagni, Venturina, et al.
Publicado: (2014)

Inhibition of lysine acetyltransferases impairs tumor angiogenesis acting on both endothelial and tumor cells
por: Di Martile, Marta, et al.
Publicado: (2020)

Emerging Role of Histone Acetyltransferase in Stem Cells and Cancer
por: Trisciuoglio, Daniela, et al.
Publicado: (2018)

The multifaceted role of lysine acetylation in cancer: prognostic biomarker and therapeutic target
por: Di Martile, Marta, et al.
Publicado: (2016)

BCL-X(L) overexpression promotes tumor progression-associated properties
por: Trisciuoglio, Daniela, et al.
Publicado: (2017)

Histone deacetylase inhibition synergistically enhances pemetrexed cytotoxicity through induction of apoptosis and autophagy in non-small cell lung cancer
por: Del Bufalo, Donatella, et al.
Publicado: (2014)

c-MYC inhibition impairs hypoxia response in glioblastoma multiforme
por: Mongiardi, Maria Patrizia, et al.
Publicado: (2016)

Metabolite profiling of ascidian Styela plicata using LC–MS with multivariate statistical analysis and their antitumor activity
por: Palanisamy, Satheesh Kumar, et al.
Publicado: (2017)

Glioblastoma Cells Do Not Affect Axitinib-Dependent Senescence of HUVECs in a Transwell Coculture Model
por: Merolle, Matilde, et al.
Publicado: (2020)

Histone deacetylase inhibitor ITF2357 leads to apoptosis and enhances doxorubicin cytotoxicity in preclinical models of human sarcoma
por: Di Martile, Marta, et al.
Publicado: (2018)

Histone acetyltransferase inhibitor CPTH6 preferentially targets lung cancer stem-like cells
por: Di Martile, Marta, et al.
Publicado: (2016)

Caspase-8 and Tyrosine Kinases: A Dangerous Liaison in Cancer
por: Contadini, Claudia, et al.
Publicado: (2023)

Pharmacological targeting of CBP/p300 drives a redox/autophagy axis leading to senescence-induced growth arrest in non-small cell lung cancer cells
por: Ansari, Mohammad Salik Zeya, et al.
Publicado: (2022)

SRC Kinase in Glioblastoma: News from an Old Acquaintance
por: Cirotti, Claudia, et al.
Publicado: (2020)

Caspase 8 Promotes Peripheral Localization and Activation of Rab5
por: Torres, Vicente A., et al.
Publicado: (2008)

Targeting the DNA Damage Response to Overcome Cancer Drug Resistance in Glioblastoma
por: Ferri, Alessandra, et al.
Publicado: (2020)

Blockage of autophagosome-lysosome fusion through SNAP29 O-GlcNAcylation promotes apoptosis via ROS production
por: Pellegrini, Francesca Romana, et al.
Publicado: (2023)

LMNA Knock-Down Affects Differentiation and Progression of Human Neuroblastoma Cells
por: Maresca, Giovanna, et al.
Publicado: (2012)

microRNA-378a-5p iS a novel positive regulator of melanoma progression
por: Tupone, Maria Grazia, et al.
Publicado: (2020)

Melanoma-specific bcl-2 promotes a protumoral M2-like phenotype by tumor-associated macrophages
por: Di Martile, Marta, et al.
Publicado: (2020)

Semaphorin 5A drives melanoma progression: role of Bcl-2, miR-204 and c-Myb
por: D’Aguanno, Simona, et al.
Publicado: (2018)

Characterization of Glioblastoma Cells Response to Regorafenib
por: Mongiardi, Maria Patrizia, et al.
Publicado: (2022)

Myc and Omomyc functionally associate with the Protein Arginine Methyltransferase 5 (PRMT5) in glioblastoma cells
por: Mongiardi, Maria Patrizia, et al.
Publicado: (2015)

Affinity purification-mass spectrometry analysis of bcl-2 interactome identified SLIRP as a novel interacting protein
por: Trisciuoglio, D, et al.
Publicado: (2016)

Several Nuclear Events during Apoptosis Depend on Caspase-3 Activation but Do Not Constitute a Common Pathway
por: Trisciuoglio, Lisa, et al.
Publicado: (2009)

Cancer Response to Therapy-Induced Senescence: A Matter of Dose and Timing
por: Mongiardi, Maria Patrizia, et al.
Publicado: (2021)

The thiazole derivative CPTH6 impairs autophagy
por: Ragazzoni, Y, et al.
Publicado: (2013)

NAADP-Dependent Ca(2+) Signaling Controls Melanoma Progression, Metastatic Dissemination and Neoangiogenesis
por: Favia, Annarita, et al.
Publicado: (2016)

PARP inhibitor ABT-888 affects response of MDA-MB-231 cells to doxorubicin treatment, targeting Snail expression
por: Mariano, Germano, et al.
Publicado: (2015)

TLR3 engagement induces IRF-3-dependent apoptosis in androgen-sensitive prostate cancer cells and inhibits tumour growth in vivo
por: Gambara, Guido, et al.
Publicado: (2015)

Effect of PACAP on Hypoxia-Induced Angiogenesis and Epithelial–Mesenchymal Transition in Glioblastoma
por: Maugeri, Grazia, et al.
Publicado: (2021)

The Tubulin Code and Tubulin-Modifying Enzymes in Autophagy and Cancer
por: Trisciuoglio, Daniela, et al.
Publicado: (2021)

NRF2 connects Src tyrosine kinase to ferroptosis resistance in glioblastoma
por: Cirotti, Claudia, et al.
Publicado: (2023)

Small molecules targeted to the microtubule–Hec1 interaction inhibit cancer cell growth through microtubule stabilization
por: Ferrara, M, et al.
Publicado: (2018)

New Agents Targeting Angiogenesis in Glioblastoma
por: Timotheadou, Eleni
Publicado: (2011)

Pseudolaric Acid B Induces Caspase-Dependent and Caspase-Independent Apoptosis in U87 Glioblastoma Cells
por: Khan, Muhammad, et al.
Publicado: (2012)

relA over-expression reduces tumorigenicity and activates apoptosis in human cancer cells
por: Ricca, A, et al.
Publicado: (2001)

Cannot write session to /tmp/vufind_sessions/sess_msajqhgnbamgrff0f10hesebq4