Cargando…

Autoinhibition of Munc18-1 modulates synaptobrevin binding and helps to enable Munc13-dependent regulation of membrane fusion

Munc18-1 orchestrates SNARE complex assembly together with Munc13-1 to mediate neurotransmitter release. Munc18-1 binds to synaptobrevin, but the relevance of this interaction and its relation to Munc13 function are unclear. NMR experiments now show that Munc18-1 binds specifically and non-specifica...

Descripción completa

Detalles Bibliográficos
Autores principales:	Sitarska, Ewa, Xu, Junjie, Park, Seungmee, Liu, Xiaoxia, Quade, Bradley, Stepien, Karolina, Sugita, Kyoko, Brautigam, Chad A, Sugita, Shuzo, Rizo, Josep
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2017
Materias:	Biophysics and Structural Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5464772/ https://www.ncbi.nlm.nih.gov/pubmed/28477408 http://dx.doi.org/10.7554/eLife.24278

Ejemplares similares

Functional synergy between the Munc13 C-terminal C(1) and C(2) domains
por: Liu, Xiaoxia, et al.
Publicado: (2016)

SNARE assembly enlightened by cryo-EM structures of a synaptobrevin–Munc18-1–syntaxin-1 complex
por: Stepien, Karolina P., et al.
Publicado: (2022)

Mechanistic insights into neurotransmitter release and presynaptic plasticity from the crystal structure of Munc13-1 C(1)C(2)BMUN
por: Xu, Junjie, et al.
Publicado: (2017)

Munc18-1-regulated stage-wise SNARE assembly underlying synaptic exocytosis
por: Ma, Lu, et al.
Publicado: (2015)

Munc13 Mediates the Transition from the Closed Syntaxin–Munc18 complex to the SNARE complex
por: Ma, Cong, et al.
Publicado: (2011)

Munc18-1 is crucial to overcome the inhibition of synaptic vesicle fusion by αSNAP
por: Stepien, Karolina P., et al.
Publicado: (2019)

Membrane bridging by Munc13-1 is crucial for neurotransmitter release
por: Quade, Bradley, et al.
Publicado: (2019)

Structural Basis for a Munc13–1 Homodimer to Munc13–1/RIM Heterodimer Switch
por: Lu, Jun, et al.
Publicado: (2006)

Munc18-Bound Syntaxin Readily Forms SNARE Complexes with Synaptobrevin in Native Plasma Membranes
por: Zilly, Felipe E, et al.
Publicado: (2006)

Membrane Bridging and Hemifusion by Denaturated Munc18
por: Xu, Yi, et al.
Publicado: (2011)

Munc18 and Munc13 regulate early neurite outgrowth
por: Broeke, Jurjen H.P., et al.
Publicado: (2010)

Control of neurotransmitter release by two distinct membrane-binding faces of the Munc13-1 C(1)C(2)B region
por: Camacho, Marcial, et al.
Publicado: (2021)

Reconciling isothermal titration calorimetry analyses of interactions between complexin and truncated SNARE complexes
por: Prinslow, Eric A, et al.
Publicado: (2017)

Neuronal SNARE complex assembly guided by Munc18‐1 and Munc13‐1
por: Wang, Shen, et al.
Publicado: (2022)

Native α-synuclein induces clustering of synaptic-vesicle mimics via binding to phospholipids and synaptobrevin-2/VAMP2
por: Diao, Jiajie, et al.
Publicado: (2013)

Structural analysis of autoinhibition in the Ras-specific exchange factor RasGRP1
por: Iwig, Jeffrey S, et al.
Publicado: (2013)

Munc18-1 domain-1 controls vesicle docking and secretion by interacting with syntaxin-1 and chaperoning it to the plasma membrane
por: Han, Gayoung A., et al.
Publicado: (2011)

Munc18 and Munc13 serve as a functional template to orchestrate neuronal SNARE complex assembly
por: Wang, Shen, et al.
Publicado: (2019)

Cryo-EM structures of the autoinhibited E. coli ATP synthase in three rotational states
por: Sobti, Meghna, et al.
Publicado: (2016)

Munc13-1 and Munc18-1 together prevent NSF-dependent de-priming of synaptic vesicles
por: He, Enqi, et al.
Publicado: (2017)

A Stimulation Function of Synaptotagmin-1 in Ternary SNARE Complex Formation Dependent on Munc18 and Munc13
por: Li, Yun, et al.
Publicado: (2017)

Munc18-1 binding to the neuronal SNARE complex controls synaptic vesicle priming
por: Deák, Ferenc, et al.
Publicado: (2009)

Munc18b Is a Major Mediator of Insulin Exocytosis in Rat Pancreatic β-Cells
por: Lam, Patrick P.L., et al.
Publicado: (2013)

CAPS and Munc13: CATCHRs that SNARE Vesicles
por: James, Declan J., et al.
Publicado: (2013)

Phorbolester-activated Munc13-1 and ubMunc13-2 exert opposing effects on dense-core vesicle secretion
por: Houy, Sébastien, et al.
Publicado: (2022)

Heterogeneous Presynaptic Distribution of Munc13 Isoforms at Retinal Synapses and Identification of an Unconventional Bipolar Cell Type with Dual Expression of Munc13 Isoforms: A Study Using Munc13-EXFP Knock-in Mice
por: Gierke, Kaspar, et al.
Publicado: (2020)

Roles of the fission yeast UNC-13/Munc13 protein Ync13 in late stages of cytokinesis
por: Zhu, Yi-Hua, et al.
Publicado: (2018)

Re-examining how complexin inhibits neurotransmitter release
por: Trimbuch, Thorsten, et al.
Publicado: (2014)

A Flexible Syntaxin Solves the Mystery of the SNAREd Munc
por: Robinson, Richard
Publicado: (2006)

Munc13 Is a Molecular Target of Bryostatin 1
por: Blanco, Francisco A., et al.
Publicado: (2019)

Heterodimerization of Munc13 C(2)A domain with RIM regulates synaptic vesicle docking and priming
por: Camacho, Marcial, et al.
Publicado: (2017)

Autoinhibition of ankyrin-B/G membrane target bindings by intrinsically disordered segments from the tail regions
por: Chen, Keyu, et al.
Publicado: (2017)

Multivalency, autoinhibition, and protein disorder in the regulation of interactions of dynein intermediate chain with dynactin and the nuclear distribution protein
por: Jara, Kayla A, et al.
Publicado: (2022)

Munc13 C(2)B-Domain – an Activity-Dependent Ca(2+)-Regulator of Synaptic Exocytosis
por: Shin, Ok-Ho, et al.
Publicado: (2010)

Dynamic Conformational Changes in MUNC18 Prevent Syntaxin Binding
por: Bar-On, Dana, et al.
Publicado: (2011)

Vesicle Fusion Probability Is Determined by the Specific Interactions of Munc18
por: Smyth, Annya M., et al.
Publicado: (2010)

Beyond the SNARE: Munc18-1 chaperones α-synuclein
por: Deshpande, Mugdha, et al.
Publicado: (2016)

Variability in the Munc13-1 content of excitatory release sites
por: Karlocai, Maria Rita, et al.
Publicado: (2021)

Munc18b Increases Insulin Granule Fusion, Restoring Deficient Insulin Secretion in Type-2 Diabetes Human and Goto-Kakizaki Rat Islets with Improvement in Glucose Homeostasis
por: Qin, Tairan, et al.
Publicado: (2017)

Munc13-Like skMLCK Variants Cannot Mimic the Unique Calmodulin Binding Mode of Munc13 as Evidenced by Chemical Cross-Linking and Mass Spectrometry
por: Herbst, Sabine, et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_lsmrqf55k6f2v0107180p0ipk0