Cargando…

Epistatic mutations in PUMA BH3 drive an alternate binding mode to potently and selectively inhibit anti-apoptotic Bfl-1

Overexpression of anti-apoptotic Bcl-2 family proteins contributes to cancer progression and confers resistance to chemotherapy. Small molecules that target Bcl-2 are used in the clinic to treat leukemia, but tight and selective inhibitors are not available for Bcl-2 paralog Bfl-1. Guided by computa...

Descripción completa

Detalles Bibliográficos
Autores principales:	Jenson, Justin M, Ryan, Jeremy A, Grant, Robert A, Letai, Anthony, Keating, Amy E
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2017
Materias:	Biochemistry and Chemical Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5464773/ https://www.ncbi.nlm.nih.gov/pubmed/28594323 http://dx.doi.org/10.7554/eLife.25541

Ejemplares similares

The carboxyl-terminal sequence of PUMA binds to both anti-apoptotic proteins and membranes
por: Pemberton, James M, et al.
Publicado: (2023)

Removal of BFL-1 sensitises some melanoma cells to killing by BH3 mimetic drugs
por: Gangoda, Lahiru, et al.
Publicado: (2022)

Puma strikes Bax
por: Letai, Anthony
Publicado: (2009)

A redox switch regulates the structure and function of anti-apoptotic BFL-1
por: Korshavn, Kyle J., et al.
Publicado: (2020)

Computational design of environmental sensors for the potent opioid fentanyl
por: Bick, Matthew J, et al.
Publicado: (2017)

Structure-based discovery of potent and selective melatonin receptor agonists
por: Patel, Nilkanth, et al.
Publicado: (2020)

Alternative activation
por: Young, Kristen, et al.
Publicado: (2023)

Neurotoxin-mediated potent activation of the axon degeneration regulator SARM1
por: Loreto, Andrea, et al.
Publicado: (2021)

The mitotic spindle protein CKAP2 potently increases formation and stability of microtubules
por: McAlear, Thomas S, et al.
Publicado: (2022)

Tailored tetravalent antibodies potently and specifically activate Wnt/Frizzled pathways in cells, organoids and mice
por: Tao, Yuyong, et al.
Publicado: (2019)

Targeting RNA:protein interactions with an integrative approach leads to the identification of potent YBX1 inhibitors
por: El Hage, Krystel, et al.
Publicado: (2023)

A distributed residue network permits conformational binding specificity in a conserved family of actin remodelers
por: Hwang, Theresa, et al.
Publicado: (2021)

Collateral deletion of the mitochondrial AAA+ ATPase ATAD1 sensitizes cancer cells to proteasome dysfunction
por: Winter, Jacob M, et al.
Publicado: (2022)

Native proline-rich motifs exploit sequence context to target actin-remodeling Ena/VASP protein ENAH
por: Hwang, Theresa, et al.
Publicado: (2022)

Anti-Apoptotic Bfl-1 Is the Major Effector in Activation-Induced Human Mast Cell Survival
por: Ekoff, Maria, et al.
Publicado: (2012)

Towards novel herbicide modes of action by inhibiting lysine biosynthesis in plants
por: Soares da Costa, Tatiana P, et al.
Publicado: (2021)

Electrostatic lateral interactions drive ESCRT-III heteropolymer assembly
por: Banjade, Sudeep, et al.
Publicado: (2019)

A conserved and regulated mechanism drives endosomal Rab transition
por: Langemeyer, Lars, et al.
Publicado: (2020)

Glypican-1 drives unconventional secretion of fibroblast growth factor 2
por: Sparn, Carola, et al.
Publicado: (2022)

Skd3 (human ClpB) is a potent mitochondrial protein disaggregase that is inactivated by 3-methylglutaconic aciduria-linked mutations
por: Cupo, Ryan R, et al.
Publicado: (2020)

A polyomavirus peptide binds to the capsid VP1 pore and has potent antiviral activity against BK and JC polyomaviruses
por: Kane, Joshua R, et al.
Publicado: (2020)

Uncovering an allosteric mode of action for a selective inhibitor of human Bloom syndrome protein
por: Chen, Xiangrong, et al.
Publicado: (2021)

A potent voltage-gated calcium channel inhibitor engineered from a nanobody targeted to auxiliary Ca(V)β subunits
por: Morgenstern, Travis J, et al.
Publicado: (2019)

A feed-forward pathway drives LRRK2 kinase membrane recruitment and activation
por: Vides, Edmundo G, et al.
Publicado: (2022)

Designed BH3 Peptides with High Affinity and Specificity for Targeting Mcl-1 in Cells
por: Foight, Glenna Wink, et al.
Publicado: (2014)

Complementary biosensors reveal different G-protein signaling modes triggered by GPCRs and non-receptor activators
por: Garcia-Marcos, Mikel
Publicado: (2021)

Mitochondrial redox adaptations enable alternative aspartate synthesis in SDH-deficient cells
por: Hart, Madeleine L, et al.
Publicado: (2023)

Tuning site-specific dynamics to drive allosteric activation in a pneumococcal zinc uptake regulator
por: Capdevila, Daiana A, et al.
Publicado: (2018)

Doublecortin engages the microtubule lattice through a cooperative binding mode involving its C-terminal domain
por: Rafiei, Atefeh, et al.
Publicado: (2022)

Discovery of a new class of reversible TEA domain transcription factor inhibitors with a novel binding mode
por: Hu, Lu, et al.
Publicado: (2022)

Inter-domain dynamics drive cholesterol transport by NPC1 and NPC1L1 proteins
por: Saha, Piyali, et al.
Publicado: (2020)

A single power stroke by ATP binding drives substrate translocation in a heterodimeric ABC transporter
por: Stefan, Erich, et al.
Publicado: (2020)

BH3-Only Proteins Noxa and Puma Are Key Regulators of Induced Apoptosis
por: Roufayel, Rabih, et al.
Publicado: (2022)

MicroRNA 3′-compensatory pairing occurs through two binding modes, with affinity shaped by nucleotide identity and position
por: McGeary, Sean E, et al.
Publicado: (2022)

Integration of IL-2 and IL-4 signals coordinates divergent regulatory T cell responses and drives therapeutic efficacy
por: Zhou, Julie Y, et al.
Publicado: (2021)

TGF-β uses a novel mode of receptor activation to phosphorylate SMAD1/5 and induce epithelial-to-mesenchymal transition
por: Ramachandran, Anassuya, et al.
Publicado: (2018)

Dynamic BH3 profiling identifies pro-apoptotic drug combinations for the treatment of malignant pleural mesothelioma
por: Potter, Danielle S., et al.
Publicado: (2023)

Glucose Induces Pancreatic Islet Cell Apoptosis That Requires the BH3-Only Proteins Bim and Puma and Multi-BH Domain Protein Bax
por: McKenzie, Mark D., et al.
Publicado: (2010)

Evaluation of pro-apoptotic potential of taxifolin against liver cancer
por: Butt, Sania Safdar, et al.
Publicado: (2021)

Chloroquine Promotes Apoptosis in Melanoma Cells by Inhibiting BH3 domain Mediated PUMA Degradation
por: Lakhter, Alexander J, et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_chciekmvtg99b05t8l1nk1m8gi