Fbxw7 haploinsufficiency loses its protection against DNA damage and accelerates MNU-induced gastric carcinogenesis

Fbxw7, a subunit of the SCF E3 ubiquitin ligase, recognizes oncoprotein substrates and leads to their proteasomal degradation. Fbxw7 acts as a tumor suppressor via inducing apoptosis and growth arrest in various kinds of tumors. To clarify the initiating role in gastric carcinogenesis as well as the...

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Detalles Bibliográficos
Autores principales: Jiang, Yannan, Qi, Xinming, Liu, Xinyu, Zhang, Jun, Ji, Jun, Zhu, Zhenggang, Ren, Jin, Yu, Yingyan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5464881/
https://www.ncbi.nlm.nih.gov/pubmed/28422719
http://dx.doi.org/10.18632/oncotarget.16800

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5464881/
https://www.ncbi.nlm.nih.gov/pubmed/28422719
http://dx.doi.org/10.18632/oncotarget.16800

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