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The dominant role of proofreading exonuclease activity of replicative polymerase ε in cellular tolerance to cytarabine (Ara-C)

Chemotherapeutic nucleoside analogs, such as Ara-C, 5-Fluorouracil (5-FU) and Trifluridine (FTD), are frequently incorporated into DNA by the replicative DNA polymerases. However, it remains unclear how this incorporation kills cycling cells. There are two possibilities: Nucleoside analog triphospha...

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Detalles Bibliográficos
Autores principales:	Tsuda, Masataka, Terada, Kazuhiro, Ooka, Masato, Kobayashi, Koji, Sasanuma, Hiroyuki, Fujisawa, Ryo, Tsurimoto, Toshiki, Yamamoto, Junpei, Iwai, Shigenori, Kadoda, Kei, Akagawa, Remi, Huang, Shar-Yin Naomi, Pommier, Yves, Sale, Julian E., Takeda, Shunichi, Hirota, Kouji
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2017
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5464882/ https://www.ncbi.nlm.nih.gov/pubmed/28380422 http://dx.doi.org/10.18632/oncotarget.16508

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