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Utilizing combinatorial engineering to develop Tie2 targeting antagonistic angiopoetin-2 ligands as candidates for anti-angiogenesis therapy

In many human cancers, the receptor tyrosine kinase (RTK) Tie2 plays important roles in mediating proliferation, survival, migration and angiogenesis. Thus, molecules that could potently inhibit activation of the Tie2 receptor would have a significant impact on cancer therapy. Nevertheless, attempts...

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Detalles Bibliográficos
Autores principales:	Shlamkovich, Tomer, Aharon, Lidan, Barton, William A., Papo, Niv
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2017
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5464891/ https://www.ncbi.nlm.nih.gov/pubmed/28422724 http://dx.doi.org/10.18632/oncotarget.16827

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