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Progressive Motor Neuron Pathology and the Role of Astrocytes in a Human Stem Cell Model of VCP-Related ALS
Motor neurons (MNs) and astrocytes (ACs) are implicated in the pathogenesis of amyotrophic lateral sclerosis (ALS), but their interaction and the sequence of molecular events leading to MN death remain unresolved. Here, we optimized directed differentiation of induced pluripotent stem cells (iPSCs)...
Autores principales: | Hall, Claire E., Yao, Zhi, Choi, Minee, Tyzack, Giulia E., Serio, Andrea, Luisier, Raphaelle, Harley, Jasmine, Preza, Elisavet, Arber, Charlie, Crisp, Sarah J., Watson, P. Marc D., Kullmann, Dimitri M., Abramov, Andrey Y., Wray, Selina, Burley, Russell, Loh, Samantha H.Y., Martins, L. Miguel, Stevens, Molly M., Luscombe, Nicholas M., Sibley, Christopher R., Lakatos, Andras, Ule, Jernej, Gandhi, Sonia, Patani, Rickie |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Cell Press
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5464993/ https://www.ncbi.nlm.nih.gov/pubmed/28564594 http://dx.doi.org/10.1016/j.celrep.2017.05.024 |
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