Transgenic overexpression of GTP cyclohydrolase 1 in cardiomyocytes ameliorates post-infarction cardiac remodeling

GTP cyclohydrolase 1 (GCH1) and its product tetrahydrobiopterin play crucial roles in cardiovascular health and disease, yet the exact regulation and role of GCH1 in adverse cardiac remodeling after myocardial infarction are still enigmatic. Here we report that cardiac GCH1 is degraded in remodeled...

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Detalles Bibliográficos
Autores principales: Liu, Yanan, Baumgardt, Shelley L., Fang, Juan, Shi, Yang, Qiao, Shigang, Bosnjak, Zeljko J., Vásquez-Vivar, Jeannette, Xia, Zhengyuan, Warltier, David C., Kersten, Judy R., Ge, Zhi-Dong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5465102/
https://www.ncbi.nlm.nih.gov/pubmed/28596578
http://dx.doi.org/10.1038/s41598-017-03234-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5465102/
https://www.ncbi.nlm.nih.gov/pubmed/28596578
http://dx.doi.org/10.1038/s41598-017-03234-6

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