GLYX-13, a NMDA Receptor Glycine-Site Functional Partial Agonist, Attenuates Cerebral Ischemia Injury In Vivo and Vitro by Differential Modulations of NMDA Receptors Subunit Components at Different Post-Ischemia Stage in Mice

Excessive activation of NMDA receptors (NMDARs) is implicated in pathological synaptic plasticity also known as post-ischemic long-term potentiation (i-LTP) which was produced by glutamate mediated excitotoxicity after stroke. In the past decades, many NMDARs inhibitors failed in clinical investigat...

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Detalles Bibliográficos
Autores principales: Zheng, Chen, Qiao, Zhi H., Hou, Meng Z., Liu, Nan N., Fu, Bin, Ding, Ran, Li, Yuan Y., Wei, Liang P., Liu, Ai L., Shen, Hui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2017
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5465280/
https://www.ncbi.nlm.nih.gov/pubmed/28649199
http://dx.doi.org/10.3389/fnagi.2017.00186

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