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Useful Effects of Melatonin in Peripheral Nerve Injury and Development of the Nervous System

This review summarizes the role of melatonin (MLT) in defense against toxic-free radicals and its novel effects in the development of the nervous system, and the effect of endogenously produced and exogenously administered MLT in reducing the degree of tissue and nerve injuries. MLT was recently rep...

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Detalles Bibliográficos
Autores principales: Uyanikgil, Yigit, Cavusoglu, Turker, Kılıc, Kubilay Dogan, Yigitturk, Gurkan, Celik, Servet, Tubbs, Richard Shane, Turgut, Mehmet
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Georg Thieme Verlag KG 2017
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5465311/
https://www.ncbi.nlm.nih.gov/pubmed/28603548
http://dx.doi.org/10.1055/s-0036-1597838
Descripción
Sumario:This review summarizes the role of melatonin (MLT) in defense against toxic-free radicals and its novel effects in the development of the nervous system, and the effect of endogenously produced and exogenously administered MLT in reducing the degree of tissue and nerve injuries. MLT was recently reported to be an effective free radical scavenger and antioxidant. Since endogenous MLT levels fall significantly in senility, these findings imply that the loss of this antioxidant could contribute to the incidence or severity of some age-related neurodegenerative diseases. Considering the high efficacy of MLT in overcoming much of the injury not only to the peripheral nerve but also to other organs, clinical trials for this purpose should be seriously considered.