Useful Effects of Melatonin in Peripheral Nerve Injury and Development of the Nervous System

This review summarizes the role of melatonin (MLT) in defense against toxic-free radicals and its novel effects in the development of the nervous system, and the effect of endogenously produced and exogenously administered MLT in reducing the degree of tissue and nerve injuries. MLT was recently rep...

Descripción completa

Detalles Bibliográficos
Autores principales: Uyanikgil, Yigit, Cavusoglu, Turker, Kılıc, Kubilay Dogan, Yigitturk, Gurkan, Celik, Servet, Tubbs, Richard Shane, Turgut, Mehmet
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Georg Thieme Verlag KG 2017
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5465311/
https://www.ncbi.nlm.nih.gov/pubmed/28603548
http://dx.doi.org/10.1055/s-0036-1597838
_version_ 1783242920657158144
author Uyanikgil, Yigit
Cavusoglu, Turker
Kılıc, Kubilay Dogan
Yigitturk, Gurkan
Celik, Servet
Tubbs, Richard Shane
Turgut, Mehmet
author_facet Uyanikgil, Yigit
Cavusoglu, Turker
Kılıc, Kubilay Dogan
Yigitturk, Gurkan
Celik, Servet
Tubbs, Richard Shane
Turgut, Mehmet
author_sort Uyanikgil, Yigit
collection PubMed
description This review summarizes the role of melatonin (MLT) in defense against toxic-free radicals and its novel effects in the development of the nervous system, and the effect of endogenously produced and exogenously administered MLT in reducing the degree of tissue and nerve injuries. MLT was recently reported to be an effective free radical scavenger and antioxidant. Since endogenous MLT levels fall significantly in senility, these findings imply that the loss of this antioxidant could contribute to the incidence or severity of some age-related neurodegenerative diseases. Considering the high efficacy of MLT in overcoming much of the injury not only to the peripheral nerve but also to other organs, clinical trials for this purpose should be seriously considered.
format Online
Article
Text
id pubmed-5465311
institution National Center for Biotechnology Information
language English
publishDate 2017
publisher Georg Thieme Verlag KG
record_format MEDLINE/PubMed
spelling pubmed-54653112017-06-09 Useful Effects of Melatonin in Peripheral Nerve Injury and Development of the Nervous System Uyanikgil, Yigit Cavusoglu, Turker Kılıc, Kubilay Dogan Yigitturk, Gurkan Celik, Servet Tubbs, Richard Shane Turgut, Mehmet J Brachial Plex Peripher Nerve Inj This review summarizes the role of melatonin (MLT) in defense against toxic-free radicals and its novel effects in the development of the nervous system, and the effect of endogenously produced and exogenously administered MLT in reducing the degree of tissue and nerve injuries. MLT was recently reported to be an effective free radical scavenger and antioxidant. Since endogenous MLT levels fall significantly in senility, these findings imply that the loss of this antioxidant could contribute to the incidence or severity of some age-related neurodegenerative diseases. Considering the high efficacy of MLT in overcoming much of the injury not only to the peripheral nerve but also to other organs, clinical trials for this purpose should be seriously considered. Georg Thieme Verlag KG 2017-02-16 /pmc/articles/PMC5465311/ /pubmed/28603548 http://dx.doi.org/10.1055/s-0036-1597838 Text en https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Uyanikgil, Yigit
Cavusoglu, Turker
Kılıc, Kubilay Dogan
Yigitturk, Gurkan
Celik, Servet
Tubbs, Richard Shane
Turgut, Mehmet
Useful Effects of Melatonin in Peripheral Nerve Injury and Development of the Nervous System
title Useful Effects of Melatonin in Peripheral Nerve Injury and Development of the Nervous System
title_full Useful Effects of Melatonin in Peripheral Nerve Injury and Development of the Nervous System
title_fullStr Useful Effects of Melatonin in Peripheral Nerve Injury and Development of the Nervous System
title_full_unstemmed Useful Effects of Melatonin in Peripheral Nerve Injury and Development of the Nervous System
title_short Useful Effects of Melatonin in Peripheral Nerve Injury and Development of the Nervous System
title_sort useful effects of melatonin in peripheral nerve injury and development of the nervous system
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5465311/
https://www.ncbi.nlm.nih.gov/pubmed/28603548
http://dx.doi.org/10.1055/s-0036-1597838
work_keys_str_mv AT uyanikgilyigit usefuleffectsofmelatonininperipheralnerveinjuryanddevelopmentofthenervoussystem
AT cavusogluturker usefuleffectsofmelatonininperipheralnerveinjuryanddevelopmentofthenervoussystem
AT kılıckubilaydogan usefuleffectsofmelatonininperipheralnerveinjuryanddevelopmentofthenervoussystem
AT yigitturkgurkan usefuleffectsofmelatonininperipheralnerveinjuryanddevelopmentofthenervoussystem
AT celikservet usefuleffectsofmelatonininperipheralnerveinjuryanddevelopmentofthenervoussystem
AT tubbsrichardshane usefuleffectsofmelatonininperipheralnerveinjuryanddevelopmentofthenervoussystem
AT turgutmehmet usefuleffectsofmelatonininperipheralnerveinjuryanddevelopmentofthenervoussystem

Ejemplares similares