The Effective Treatment of Lung Infection Due to Scedosporium prolificans with Voriconazole and Surgery

Scedosporium prolificans is a fungus that has demonstrated resistance against most currently available antifungal agents and which causes a rapidly disseminating and potentially fatal infection. A 68-year-old woman presented with a fever and consolidation in the lung field. Her symptoms and inflamma...

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Autores principales: Masukane, Seiya, Kitahara, Yoshihiro, Okumoto, Joe, Sasaki, Keisuke, Nakano, Kikuo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Internal Medicine 2017
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5465417/
https://www.ncbi.nlm.nih.gov/pubmed/28420849
http://dx.doi.org/10.2169/internalmedicine.56.7447
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author Masukane, Seiya
Kitahara, Yoshihiro
Okumoto, Joe
Sasaki, Keisuke
Nakano, Kikuo
author_facet Masukane, Seiya
Kitahara, Yoshihiro
Okumoto, Joe
Sasaki, Keisuke
Nakano, Kikuo
author_sort Masukane, Seiya
collection PubMed
description Scedosporium prolificans is a fungus that has demonstrated resistance against most currently available antifungal agents and which causes a rapidly disseminating and potentially fatal infection. A 68-year-old woman presented with a fever and consolidation in the lung field. Her symptoms and inflammatory reaction did not improve despite treatment with tazobactam/piperacillin, meropenem, and micafungin. Scedosporium prolificans was detected from the patient's bronchial lavage fluid, and we initiated treatment with voriconazole. Voriconazole was effective in shrinking the consolidation and suppressing the inflammatory reaction. The residual lesion was surgically resected because of the risk of systemic dissemination. The patient is currently alive without relapse or dissemination.
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spelling pubmed-54654172017-06-19 The Effective Treatment of Lung Infection Due to Scedosporium prolificans with Voriconazole and Surgery Masukane, Seiya Kitahara, Yoshihiro Okumoto, Joe Sasaki, Keisuke Nakano, Kikuo Intern Med Case Report Scedosporium prolificans is a fungus that has demonstrated resistance against most currently available antifungal agents and which causes a rapidly disseminating and potentially fatal infection. A 68-year-old woman presented with a fever and consolidation in the lung field. Her symptoms and inflammatory reaction did not improve despite treatment with tazobactam/piperacillin, meropenem, and micafungin. Scedosporium prolificans was detected from the patient's bronchial lavage fluid, and we initiated treatment with voriconazole. Voriconazole was effective in shrinking the consolidation and suppressing the inflammatory reaction. The residual lesion was surgically resected because of the risk of systemic dissemination. The patient is currently alive without relapse or dissemination. The Japanese Society of Internal Medicine 2017-04-15 /pmc/articles/PMC5465417/ /pubmed/28420849 http://dx.doi.org/10.2169/internalmedicine.56.7447 Text en Copyright © 2017 by The Japanese Society of Internal Medicine https://creativecommons.org/licenses/by-nc-nd/4.0/ The Internal Medicine is an Open Access article distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view the details of this license, please visit (https://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Masukane, Seiya
Kitahara, Yoshihiro
Okumoto, Joe
Sasaki, Keisuke
Nakano, Kikuo
The Effective Treatment of Lung Infection Due to Scedosporium prolificans with Voriconazole and Surgery
title The Effective Treatment of Lung Infection Due to Scedosporium prolificans with Voriconazole and Surgery
title_full The Effective Treatment of Lung Infection Due to Scedosporium prolificans with Voriconazole and Surgery
title_fullStr The Effective Treatment of Lung Infection Due to Scedosporium prolificans with Voriconazole and Surgery
title_full_unstemmed The Effective Treatment of Lung Infection Due to Scedosporium prolificans with Voriconazole and Surgery
title_short The Effective Treatment of Lung Infection Due to Scedosporium prolificans with Voriconazole and Surgery
title_sort effective treatment of lung infection due to scedosporium prolificans with voriconazole and surgery
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5465417/
https://www.ncbi.nlm.nih.gov/pubmed/28420849
http://dx.doi.org/10.2169/internalmedicine.56.7447
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