Alert Regarding Cisplatin-induced Severe Adverse Events in Cancer Patients with Xeroderma Pigmentosum

Xeroderma pigmentosum (XP) is a genetic disease in which DNA repair mechanisms are impaired. Cisplatin (CDDP) exerts cytotoxic effects by forming mainly intrastrand DNA cross-links, and sensitivity to CDDP depends on the DNA repair system. Several in vitro studies have suggested that treatment with...

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Autores principales: Sumiyoshi, Makoto, Soda, Hiroshi, Sadanaga, Noriaki, Taniguchi, Hirokazu, Ikeda, Takaya, Maruta, Hiroshi, Dotsu, Yosuke, Ogawara, Daiki, Fukuda, Yuichi, Mukae, Hiroshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Internal Medicine 2017
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5465418/
https://www.ncbi.nlm.nih.gov/pubmed/28420850
http://dx.doi.org/10.2169/internalmedicine.56.7866
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author Sumiyoshi, Makoto
Soda, Hiroshi
Sadanaga, Noriaki
Taniguchi, Hirokazu
Ikeda, Takaya
Maruta, Hiroshi
Dotsu, Yosuke
Ogawara, Daiki
Fukuda, Yuichi
Mukae, Hiroshi
author_facet Sumiyoshi, Makoto
Soda, Hiroshi
Sadanaga, Noriaki
Taniguchi, Hirokazu
Ikeda, Takaya
Maruta, Hiroshi
Dotsu, Yosuke
Ogawara, Daiki
Fukuda, Yuichi
Mukae, Hiroshi
author_sort Sumiyoshi, Makoto
collection PubMed
description Xeroderma pigmentosum (XP) is a genetic disease in which DNA repair mechanisms are impaired. Cisplatin (CDDP) exerts cytotoxic effects by forming mainly intrastrand DNA cross-links, and sensitivity to CDDP depends on the DNA repair system. Several in vitro studies have suggested that treatment with CDDP may cause enhanced adverse events as well as anti-tumor activity in cancer patients with XP. This article is the first to describe two cancer patients with XP showing severe adverse events following CDDP-based chemotherapy. Physicians should pay attention when administering CDDP in cancer patients with XP.
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spelling pubmed-54654182017-06-19 Alert Regarding Cisplatin-induced Severe Adverse Events in Cancer Patients with Xeroderma Pigmentosum Sumiyoshi, Makoto Soda, Hiroshi Sadanaga, Noriaki Taniguchi, Hirokazu Ikeda, Takaya Maruta, Hiroshi Dotsu, Yosuke Ogawara, Daiki Fukuda, Yuichi Mukae, Hiroshi Intern Med Case Report Xeroderma pigmentosum (XP) is a genetic disease in which DNA repair mechanisms are impaired. Cisplatin (CDDP) exerts cytotoxic effects by forming mainly intrastrand DNA cross-links, and sensitivity to CDDP depends on the DNA repair system. Several in vitro studies have suggested that treatment with CDDP may cause enhanced adverse events as well as anti-tumor activity in cancer patients with XP. This article is the first to describe two cancer patients with XP showing severe adverse events following CDDP-based chemotherapy. Physicians should pay attention when administering CDDP in cancer patients with XP. The Japanese Society of Internal Medicine 2017-04-15 /pmc/articles/PMC5465418/ /pubmed/28420850 http://dx.doi.org/10.2169/internalmedicine.56.7866 Text en Copyright © 2017 by The Japanese Society of Internal Medicine https://creativecommons.org/licenses/by-nc-nd/4.0/ The Internal Medicine is an Open Access article distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view the details of this license, please visit (https://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Sumiyoshi, Makoto
Soda, Hiroshi
Sadanaga, Noriaki
Taniguchi, Hirokazu
Ikeda, Takaya
Maruta, Hiroshi
Dotsu, Yosuke
Ogawara, Daiki
Fukuda, Yuichi
Mukae, Hiroshi
Alert Regarding Cisplatin-induced Severe Adverse Events in Cancer Patients with Xeroderma Pigmentosum
title Alert Regarding Cisplatin-induced Severe Adverse Events in Cancer Patients with Xeroderma Pigmentosum
title_full Alert Regarding Cisplatin-induced Severe Adverse Events in Cancer Patients with Xeroderma Pigmentosum
title_fullStr Alert Regarding Cisplatin-induced Severe Adverse Events in Cancer Patients with Xeroderma Pigmentosum
title_full_unstemmed Alert Regarding Cisplatin-induced Severe Adverse Events in Cancer Patients with Xeroderma Pigmentosum
title_short Alert Regarding Cisplatin-induced Severe Adverse Events in Cancer Patients with Xeroderma Pigmentosum
title_sort alert regarding cisplatin-induced severe adverse events in cancer patients with xeroderma pigmentosum
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5465418/
https://www.ncbi.nlm.nih.gov/pubmed/28420850
http://dx.doi.org/10.2169/internalmedicine.56.7866
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