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Renal-Limited “Lupus-Like” Nephritis: How Much of a Lupus?
Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by development of autoantibodies to nuclear and cytoplasmic antigens. A small subset of SLE patients who had the typical clinical features of SLE was reported to show persistently negative antinuclear antibody tests. Our repor...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
S. Karger AG
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5465519/ https://www.ncbi.nlm.nih.gov/pubmed/28612005 http://dx.doi.org/10.1159/000475493 |
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author | Maziad, Asmaa S. Abu Torrealba, Jose Seikaly, Mouin G. Hassler, Jared R. Hendricks, Allen R. |
author_facet | Maziad, Asmaa S. Abu Torrealba, Jose Seikaly, Mouin G. Hassler, Jared R. Hendricks, Allen R. |
author_sort | Maziad, Asmaa S. Abu |
collection | PubMed |
description | Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by development of autoantibodies to nuclear and cytoplasmic antigens. A small subset of SLE patients who had the typical clinical features of SLE was reported to show persistently negative antinuclear antibody tests. Our report describes a 5-year-old male who presented with histopathological findings suggestive of lupus nephritis with no clinical signs or symptoms of SLE and negative autoantibodies. He was treated with corticosteroids, mycophenolate mofetil, and monthly intravenous cyclophosphamide. During the 2-year follow-up period, the proteinuria resolved and kidney function improved with continued negative autoantibody workup. This case presents a category of renal-limited “lupus-like” glomerulonephritis which can be challenging to treat and carries a poor prognosis. |
format | Online Article Text |
id | pubmed-5465519 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | S. Karger AG |
record_format | MEDLINE/PubMed |
spelling | pubmed-54655192017-06-13 Renal-Limited “Lupus-Like” Nephritis: How Much of a Lupus? Maziad, Asmaa S. Abu Torrealba, Jose Seikaly, Mouin G. Hassler, Jared R. Hendricks, Allen R. Case Rep Nephrol Dial Case Report Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by development of autoantibodies to nuclear and cytoplasmic antigens. A small subset of SLE patients who had the typical clinical features of SLE was reported to show persistently negative antinuclear antibody tests. Our report describes a 5-year-old male who presented with histopathological findings suggestive of lupus nephritis with no clinical signs or symptoms of SLE and negative autoantibodies. He was treated with corticosteroids, mycophenolate mofetil, and monthly intravenous cyclophosphamide. During the 2-year follow-up period, the proteinuria resolved and kidney function improved with continued negative autoantibody workup. This case presents a category of renal-limited “lupus-like” glomerulonephritis which can be challenging to treat and carries a poor prognosis. S. Karger AG 2017-05-08 /pmc/articles/PMC5465519/ /pubmed/28612005 http://dx.doi.org/10.1159/000475493 Text en Copyright © 2017 by S. Karger AG, Basel http://creativecommons.org/licenses/by-nc/4.0/ This article is licensed under the Creative Commons Attribution-NonCommercial-4.0 International License (CC BY-NC) (http://www.karger.com/Services/OpenAccessLicense). Usage and distribution for commercial purposes requires written permission. |
spellingShingle | Case Report Maziad, Asmaa S. Abu Torrealba, Jose Seikaly, Mouin G. Hassler, Jared R. Hendricks, Allen R. Renal-Limited “Lupus-Like” Nephritis: How Much of a Lupus? |
title | Renal-Limited “Lupus-Like” Nephritis: How Much of a Lupus? |
title_full | Renal-Limited “Lupus-Like” Nephritis: How Much of a Lupus? |
title_fullStr | Renal-Limited “Lupus-Like” Nephritis: How Much of a Lupus? |
title_full_unstemmed | Renal-Limited “Lupus-Like” Nephritis: How Much of a Lupus? |
title_short | Renal-Limited “Lupus-Like” Nephritis: How Much of a Lupus? |
title_sort | renal-limited “lupus-like” nephritis: how much of a lupus? |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5465519/ https://www.ncbi.nlm.nih.gov/pubmed/28612005 http://dx.doi.org/10.1159/000475493 |
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