Two SPINK1 Mutations Induce Early-Onset Severe Chronic Pancreatitis

The SPINK1 protein is a potent antiprotease that can inactivate any intrapancreatic trypsin activity that would otherwise induce autodigestion of the pancreas. SPINK1 mutations have been recognized to be associated with chronic pancreatitis in patients without a family history of pancreatitis. We he...

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Detalles Bibliográficos
Autores principales: Frossard, Jean Louis, Morris, Michael A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: S. Karger AG 2017
Materias:
Case and Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5465701/
https://www.ncbi.nlm.nih.gov/pubmed/28611558
http://dx.doi.org/10.1159/000456654
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author Frossard, Jean Louis
Morris, Michael A.
author_facet Frossard, Jean Louis
Morris, Michael A.
author_sort Frossard, Jean Louis
collection PubMed
description The SPINK1 protein is a potent antiprotease that can inactivate any intrapancreatic trypsin activity that would otherwise induce autodigestion of the pancreas. SPINK1 mutations have been recognized to be associated with chronic pancreatitis in patients without a family history of pancreatitis. We here describe the case of a 24-year-old woman referred to our service for recurrent abdominal pain and search for the cause of chronic calcifying pancreatitis, who was found to carry 2 SPINK1 mutations.
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spelling pubmed-54657012017-06-13 Two SPINK1 Mutations Induce Early-Onset Severe Chronic Pancreatitis Frossard, Jean Louis Morris, Michael A. Case Rep Gastroenterol Case and Review The SPINK1 protein is a potent antiprotease that can inactivate any intrapancreatic trypsin activity that would otherwise induce autodigestion of the pancreas. SPINK1 mutations have been recognized to be associated with chronic pancreatitis in patients without a family history of pancreatitis. We here describe the case of a 24-year-old woman referred to our service for recurrent abdominal pain and search for the cause of chronic calcifying pancreatitis, who was found to carry 2 SPINK1 mutations. S. Karger AG 2017-03-03 /pmc/articles/PMC5465701/ /pubmed/28611558 http://dx.doi.org/10.1159/000456654 Text en Copyright © 2017 by S. Karger AG, Basel http://creativecommons.org/licenses/by-nc/4.0/ This article is licensed under the Creative Commons Attribution-NonCommercial-4.0 International License (CC BY-NC) (http://www.karger.com/Services/OpenAccessLicense). Usage and distribution for commercial purposes requires written permission.
spellingShingle Case and Review
Frossard, Jean Louis
Morris, Michael A.
Two SPINK1 Mutations Induce Early-Onset Severe Chronic Pancreatitis
title Two SPINK1 Mutations Induce Early-Onset Severe Chronic Pancreatitis
title_full Two SPINK1 Mutations Induce Early-Onset Severe Chronic Pancreatitis
title_fullStr Two SPINK1 Mutations Induce Early-Onset Severe Chronic Pancreatitis
title_full_unstemmed Two SPINK1 Mutations Induce Early-Onset Severe Chronic Pancreatitis
title_short Two SPINK1 Mutations Induce Early-Onset Severe Chronic Pancreatitis
title_sort two spink1 mutations induce early-onset severe chronic pancreatitis
topic Case and Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5465701/
https://www.ncbi.nlm.nih.gov/pubmed/28611558
http://dx.doi.org/10.1159/000456654
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