An intrabody specific for the nucleophosmin carboxy-terminal mutant and fused to a nuclear localization sequence binds its antigen but fails to relocate it in the nucleus

The cytoplasmic accumulation of NPM1 (NPMc+) is found in acute myeloid leukemia (AML) with NPM1 mutation. NPM1 must shuttle between nucleus and cytoplasm to assure physiological protein synthesis and, therefore, the elimination of NPMc+ is not a suitable therapeutic option. We isolated, characterize...

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Detalles Bibliográficos
Autores principales: Martinelli, Chiara, Colombo, Emanuela, Piccini, Daniele, Sironi, Cristina, Pelicci, Pier Giuseppe, de Marco, Ario
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5466097/
https://www.ncbi.nlm.nih.gov/pubmed/28626645
http://dx.doi.org/10.1016/j.btre.2014.05.008

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