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Diabetes self-assessment score and the development of diabetes: A 10-year prospective study
To verify that the Korean Diabetes Score (KDS), a self-assessment, predicts the risk of diabetes in various comprehensive risk models, and to investigate factors that enhance its predictive ability in a large cohort. We analyzed 8735 adults without diabetes in the Korean Genome and Epidemiology Stud...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Wolters Kluwer Health
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5466221/ https://www.ncbi.nlm.nih.gov/pubmed/28591043 http://dx.doi.org/10.1097/MD.0000000000007067 |
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author | Kim, Gyuri Lee, Yong-ho Lee, Byung-Wan Kang, Eun Seok Lee, In-Kyu Cha, Bong-Soo Kim, Dae Jung |
author_facet | Kim, Gyuri Lee, Yong-ho Lee, Byung-Wan Kang, Eun Seok Lee, In-Kyu Cha, Bong-Soo Kim, Dae Jung |
author_sort | Kim, Gyuri |
collection | PubMed |
description | To verify that the Korean Diabetes Score (KDS), a self-assessment, predicts the risk of diabetes in various comprehensive risk models, and to investigate factors that enhance its predictive ability in a large cohort. We analyzed 8735 adults without diabetes in the Korean Genome and Epidemiology Study, an ongoing large community-based 10-year cohort study. Incident diabetes was defined as fasting blood glucose ≥126 mg/dL or postload 2-hour glucose ≥200 mg/dL by 75 g oral glucose tolerance test conducted biennually, or currently taking medication for diabetes. Hazard ratios (HRs) using Cox regression were calculated for relative risk of developing diabetes as associated with the KDS, and performance of risk models was assessed by area under the receiver-operating characteristic curve (AUC). Of 8735 participants, 1497 (17.1%) developed diabetes over 10 years. The prevalence of incident diabetes was 10.3% in people with a KDS <5 and was 21.8% in those with KDS ≥5 (P < .001). Increasing KDS was significantly associated with developing diabetes (adjusted HR: 1.13; 95% confidence interval:1.09,1.18). The comprehensive prediction model with KDS added to fasting glucose, glycated hemoglobin, postload 2-hour glucose, and triglyceride showed a markedly higher AUC (0.782) compared to KDS alone (0.641). A low insulinogenic index (IGI) level, but not insulin resistance, was a significant determinant of developing diabetes in subjects who had baseline KDS < 5. We confirmed that KDS as a 10-year risk model to predict diabetes becomes more potent when added to relevant laboratory parameters. Beta-cell function as assessed by IGI should be taken into account when predicting diabetes using the KDS. |
format | Online Article Text |
id | pubmed-5466221 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Wolters Kluwer Health |
record_format | MEDLINE/PubMed |
spelling | pubmed-54662212017-06-15 Diabetes self-assessment score and the development of diabetes: A 10-year prospective study Kim, Gyuri Lee, Yong-ho Lee, Byung-Wan Kang, Eun Seok Lee, In-Kyu Cha, Bong-Soo Kim, Dae Jung Medicine (Baltimore) 4300 To verify that the Korean Diabetes Score (KDS), a self-assessment, predicts the risk of diabetes in various comprehensive risk models, and to investigate factors that enhance its predictive ability in a large cohort. We analyzed 8735 adults without diabetes in the Korean Genome and Epidemiology Study, an ongoing large community-based 10-year cohort study. Incident diabetes was defined as fasting blood glucose ≥126 mg/dL or postload 2-hour glucose ≥200 mg/dL by 75 g oral glucose tolerance test conducted biennually, or currently taking medication for diabetes. Hazard ratios (HRs) using Cox regression were calculated for relative risk of developing diabetes as associated with the KDS, and performance of risk models was assessed by area under the receiver-operating characteristic curve (AUC). Of 8735 participants, 1497 (17.1%) developed diabetes over 10 years. The prevalence of incident diabetes was 10.3% in people with a KDS <5 and was 21.8% in those with KDS ≥5 (P < .001). Increasing KDS was significantly associated with developing diabetes (adjusted HR: 1.13; 95% confidence interval:1.09,1.18). The comprehensive prediction model with KDS added to fasting glucose, glycated hemoglobin, postload 2-hour glucose, and triglyceride showed a markedly higher AUC (0.782) compared to KDS alone (0.641). A low insulinogenic index (IGI) level, but not insulin resistance, was a significant determinant of developing diabetes in subjects who had baseline KDS < 5. We confirmed that KDS as a 10-year risk model to predict diabetes becomes more potent when added to relevant laboratory parameters. Beta-cell function as assessed by IGI should be taken into account when predicting diabetes using the KDS. Wolters Kluwer Health 2017-06-08 /pmc/articles/PMC5466221/ /pubmed/28591043 http://dx.doi.org/10.1097/MD.0000000000007067 Text en Copyright © 2017 the Author(s). Published by Wolters Kluwer Health, Inc. http://creativecommons.org/licenses/by-nc-sa/4.0 This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms. http://creativecommons.org/licenses/by-nc-sa/4.0 |
spellingShingle | 4300 Kim, Gyuri Lee, Yong-ho Lee, Byung-Wan Kang, Eun Seok Lee, In-Kyu Cha, Bong-Soo Kim, Dae Jung Diabetes self-assessment score and the development of diabetes: A 10-year prospective study |
title | Diabetes self-assessment score and the development of diabetes: A 10-year prospective study |
title_full | Diabetes self-assessment score and the development of diabetes: A 10-year prospective study |
title_fullStr | Diabetes self-assessment score and the development of diabetes: A 10-year prospective study |
title_full_unstemmed | Diabetes self-assessment score and the development of diabetes: A 10-year prospective study |
title_short | Diabetes self-assessment score and the development of diabetes: A 10-year prospective study |
title_sort | diabetes self-assessment score and the development of diabetes: a 10-year prospective study |
topic | 4300 |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5466221/ https://www.ncbi.nlm.nih.gov/pubmed/28591043 http://dx.doi.org/10.1097/MD.0000000000007067 |
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