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Immunogenicity study to investigate the interchangeability among three different types of polio vaccine: A cohort study in Japan

In Japan, the routine immunization program with oral polio vaccine (OPV) has been suspended since September 2012, when a program with 4 doses of inactivated monovalent polio vaccine (IPV) or quadrivalent vaccine against diphtheria, pertussis, and tetanus with IPV (DTaP-IPV) was introduced. The aim o...

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Autores principales: Ohfuji, Satoko, Ito, Kazuya, Ishibashi, Motoki, Shindo, Shizuo, Takasaki, Yoshio, Yokoyama, Takashi, Yokoyama, Takato, Yamashita, Yuji, Shibao, Keigo, Nakano, Takashi, Tsuru, Tomomi, Irie, Shin, Hirota, Yoshio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer Health 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5466224/
https://www.ncbi.nlm.nih.gov/pubmed/28591046
http://dx.doi.org/10.1097/MD.0000000000007073
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author Ohfuji, Satoko
Ito, Kazuya
Ishibashi, Motoki
Shindo, Shizuo
Takasaki, Yoshio
Yokoyama, Takashi
Yokoyama, Takato
Yamashita, Yuji
Shibao, Keigo
Nakano, Takashi
Tsuru, Tomomi
Irie, Shin
Hirota, Yoshio
author_facet Ohfuji, Satoko
Ito, Kazuya
Ishibashi, Motoki
Shindo, Shizuo
Takasaki, Yoshio
Yokoyama, Takashi
Yokoyama, Takato
Yamashita, Yuji
Shibao, Keigo
Nakano, Takashi
Tsuru, Tomomi
Irie, Shin
Hirota, Yoshio
author_sort Ohfuji, Satoko
collection PubMed
description In Japan, the routine immunization program with oral polio vaccine (OPV) has been suspended since September 2012, when a program with 4 doses of inactivated monovalent polio vaccine (IPV) or quadrivalent vaccine against diphtheria, pertussis, and tetanus with IPV (DTaP-IPV) was introduced. The aim of this study was to examine the interchangeability among these 3 types of polio vaccines. We conducted a prospective cohort study at 5 pediatric clinics in Japan. A total of 153 infants were assigned to 1 of the 4 groups by considering the vaccination history of OPV and trivalent vaccine against DTaP. Eleven infants with a history of OPV received 3 doses of DTaP-IPV; 49 infants with a history of OPV and DTaP received 3 doses of IPV; 50 polio vaccine-naïve infants received 2 doses of IPV followed by 2 doses of DTaP-IPV; and 43 polio vaccine-naive infants received 2 doses of DTaP-IPV followed by IPV. The immunogenicity after polio vaccination was evaluated among these 4 groups. After 2 doses of polio vaccination, more than 80% of the infants exhibited a neutralization antibody titer ≥1:8 for all Sabin strains and wild strains in all groups. After the third dose, the seroprotection proportion (i.e., a neutralization antibody titer ≥1:8) reached about 100%. After the fourth dose, a neutralization antibody titer exceeded the required protective levels (i.e., a neutralization antibody titer ≥1:8) considerably in all groups. Four doses of polio vaccines induced a sufficient level of immunity in Japanese infants, irrespective of vaccine combinations or order.
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spelling pubmed-54662242017-06-15 Immunogenicity study to investigate the interchangeability among three different types of polio vaccine: A cohort study in Japan Ohfuji, Satoko Ito, Kazuya Ishibashi, Motoki Shindo, Shizuo Takasaki, Yoshio Yokoyama, Takashi Yokoyama, Takato Yamashita, Yuji Shibao, Keigo Nakano, Takashi Tsuru, Tomomi Irie, Shin Hirota, Yoshio Medicine (Baltimore) 4900 In Japan, the routine immunization program with oral polio vaccine (OPV) has been suspended since September 2012, when a program with 4 doses of inactivated monovalent polio vaccine (IPV) or quadrivalent vaccine against diphtheria, pertussis, and tetanus with IPV (DTaP-IPV) was introduced. The aim of this study was to examine the interchangeability among these 3 types of polio vaccines. We conducted a prospective cohort study at 5 pediatric clinics in Japan. A total of 153 infants were assigned to 1 of the 4 groups by considering the vaccination history of OPV and trivalent vaccine against DTaP. Eleven infants with a history of OPV received 3 doses of DTaP-IPV; 49 infants with a history of OPV and DTaP received 3 doses of IPV; 50 polio vaccine-naïve infants received 2 doses of IPV followed by 2 doses of DTaP-IPV; and 43 polio vaccine-naive infants received 2 doses of DTaP-IPV followed by IPV. The immunogenicity after polio vaccination was evaluated among these 4 groups. After 2 doses of polio vaccination, more than 80% of the infants exhibited a neutralization antibody titer ≥1:8 for all Sabin strains and wild strains in all groups. After the third dose, the seroprotection proportion (i.e., a neutralization antibody titer ≥1:8) reached about 100%. After the fourth dose, a neutralization antibody titer exceeded the required protective levels (i.e., a neutralization antibody titer ≥1:8) considerably in all groups. Four doses of polio vaccines induced a sufficient level of immunity in Japanese infants, irrespective of vaccine combinations or order. Wolters Kluwer Health 2017-06-08 /pmc/articles/PMC5466224/ /pubmed/28591046 http://dx.doi.org/10.1097/MD.0000000000007073 Text en Copyright © 2017 the Author(s). Published by Wolters Kluwer Health, Inc. http://creativecommons.org/licenses/by/4.0 This is an open access article distributed under the Creative Commons Attribution License 4.0 (CCBY), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. http://creativecommons.org/licenses/by/4.0
spellingShingle 4900
Ohfuji, Satoko
Ito, Kazuya
Ishibashi, Motoki
Shindo, Shizuo
Takasaki, Yoshio
Yokoyama, Takashi
Yokoyama, Takato
Yamashita, Yuji
Shibao, Keigo
Nakano, Takashi
Tsuru, Tomomi
Irie, Shin
Hirota, Yoshio
Immunogenicity study to investigate the interchangeability among three different types of polio vaccine: A cohort study in Japan
title Immunogenicity study to investigate the interchangeability among three different types of polio vaccine: A cohort study in Japan
title_full Immunogenicity study to investigate the interchangeability among three different types of polio vaccine: A cohort study in Japan
title_fullStr Immunogenicity study to investigate the interchangeability among three different types of polio vaccine: A cohort study in Japan
title_full_unstemmed Immunogenicity study to investigate the interchangeability among three different types of polio vaccine: A cohort study in Japan
title_short Immunogenicity study to investigate the interchangeability among three different types of polio vaccine: A cohort study in Japan
title_sort immunogenicity study to investigate the interchangeability among three different types of polio vaccine: a cohort study in japan
topic 4900
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5466224/
https://www.ncbi.nlm.nih.gov/pubmed/28591046
http://dx.doi.org/10.1097/MD.0000000000007073
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