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Seroprevalence and clinical characteristics of viral hepatitis in transfusion-dependent thalassemia and hemophilia patients
BACKGROUND/AIMS: Transfusion dependent subjects are at a great risk of viral hepatitis infection. We aimed to evaluate the prevalence and factors associated with hepatitis B virus (HBV) and hepatitis C virus (HCV) infection among transfusion-dependent patients in Taiwan. METHODS: A total of 140 pati...
Autores principales: | , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5466320/ https://www.ncbi.nlm.nih.gov/pubmed/28598970 http://dx.doi.org/10.1371/journal.pone.0178883 |
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author | Jang, Tyng-Yuan Lin, Pei-Chin Huang, Ching-I Liao, Yu-Mei Yeh, Ming-Lun Zeng, Yu-Sheng Liang, Po-Cheng Hsu, Wan-Yi Tsai, Shih-Pien Lin, Zu-Yau Chen, Shinn-Cherng Huang, Jee-Fu Dai, Chia-Yen Huang, Chung-Feng Chiou, Shyh-Shin Chuang, Wan-Long Yu, Ming-Lung |
author_facet | Jang, Tyng-Yuan Lin, Pei-Chin Huang, Ching-I Liao, Yu-Mei Yeh, Ming-Lun Zeng, Yu-Sheng Liang, Po-Cheng Hsu, Wan-Yi Tsai, Shih-Pien Lin, Zu-Yau Chen, Shinn-Cherng Huang, Jee-Fu Dai, Chia-Yen Huang, Chung-Feng Chiou, Shyh-Shin Chuang, Wan-Long Yu, Ming-Lung |
author_sort | Jang, Tyng-Yuan |
collection | PubMed |
description | BACKGROUND/AIMS: Transfusion dependent subjects are at a great risk of viral hepatitis infection. We aimed to evaluate the prevalence and factors associated with hepatitis B virus (HBV) and hepatitis C virus (HCV) infection among transfusion-dependent patients in Taiwan. METHODS: A total of 140 patients (67 thalassemic patients, 70 hemophilic patients, two patients with hereditary spherocytosis and one patient with von Willebrand disease) were prospectively enrolled to evaluate the prevalence and factors associated with viral hepatitis and spontaneous HCV clearance. All patients were tested for HBV and HCV serology and virology. Two consecutive serum samples, at least 1 year apart, were collected to clarify HCV seroclearance. RESULTS: The seropositivity rate of hepatitis B surface antigen (HBsAg), HCV antibody (anti-HCV), and both HBsAg/anti-HCV were 6.4%, 45.7% and 5%, respectively. Logistic regression analysis of factors associated with anti-HCV seropositivity included age (odds ratio/95% confidence interval [OR/CI]: 1.12/1.07–1.18, P<0.001), serum alanine aminotransferase (ALT) (OR/CI: 1.04/1.02–1.06, P<0.001) and platelet counts (OR/CI: 0.995/0.991–0.998, P = 0.002). Age was the only factor independently associated with HBsAg seropositivity (OR/CI: 1.08/1.02–1.14.4, P = 0.007). Compared to patients born before 1992, the seroprevalence of HCV among thalassemic patients decreased dramatically in those born after 1992 (46.0% vs. 11.8%, p = 0.012). The seroprevalence of HCV among hemophilic patients also decreased significantly when comparing patients born before 1987 to those born after 1987 (79.5% vs. 11.5%, p<0.001). Similarly, the seroprevalence of HBV decreased significantly in the post-vaccination cohort compared to its counterpart (13.1%, vs. 1.3%, p = 0.005). The spontaneous clearance of HCV was observed in 25.4% (15/59) of patients, and ALT was the only factor associated with it (OR/CI 0.98/0.96–1.00, P = 0.02). CONCLUSIONS: Both HBV and HCV infections are prevalent among transfusion-dependent thalassemic and hemophilic patients in Taiwan. Nevertheless, seroprevalence decreased significantly and dramatically for HCV after universal blood screening and for HBV after implementation of a universal mass vaccination program. |
format | Online Article Text |
id | pubmed-5466320 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-54663202017-06-22 Seroprevalence and clinical characteristics of viral hepatitis in transfusion-dependent thalassemia and hemophilia patients Jang, Tyng-Yuan Lin, Pei-Chin Huang, Ching-I Liao, Yu-Mei Yeh, Ming-Lun Zeng, Yu-Sheng Liang, Po-Cheng Hsu, Wan-Yi Tsai, Shih-Pien Lin, Zu-Yau Chen, Shinn-Cherng Huang, Jee-Fu Dai, Chia-Yen Huang, Chung-Feng Chiou, Shyh-Shin Chuang, Wan-Long Yu, Ming-Lung PLoS One Research Article BACKGROUND/AIMS: Transfusion dependent subjects are at a great risk of viral hepatitis infection. We aimed to evaluate the prevalence and factors associated with hepatitis B virus (HBV) and hepatitis C virus (HCV) infection among transfusion-dependent patients in Taiwan. METHODS: A total of 140 patients (67 thalassemic patients, 70 hemophilic patients, two patients with hereditary spherocytosis and one patient with von Willebrand disease) were prospectively enrolled to evaluate the prevalence and factors associated with viral hepatitis and spontaneous HCV clearance. All patients were tested for HBV and HCV serology and virology. Two consecutive serum samples, at least 1 year apart, were collected to clarify HCV seroclearance. RESULTS: The seropositivity rate of hepatitis B surface antigen (HBsAg), HCV antibody (anti-HCV), and both HBsAg/anti-HCV were 6.4%, 45.7% and 5%, respectively. Logistic regression analysis of factors associated with anti-HCV seropositivity included age (odds ratio/95% confidence interval [OR/CI]: 1.12/1.07–1.18, P<0.001), serum alanine aminotransferase (ALT) (OR/CI: 1.04/1.02–1.06, P<0.001) and platelet counts (OR/CI: 0.995/0.991–0.998, P = 0.002). Age was the only factor independently associated with HBsAg seropositivity (OR/CI: 1.08/1.02–1.14.4, P = 0.007). Compared to patients born before 1992, the seroprevalence of HCV among thalassemic patients decreased dramatically in those born after 1992 (46.0% vs. 11.8%, p = 0.012). The seroprevalence of HCV among hemophilic patients also decreased significantly when comparing patients born before 1987 to those born after 1987 (79.5% vs. 11.5%, p<0.001). Similarly, the seroprevalence of HBV decreased significantly in the post-vaccination cohort compared to its counterpart (13.1%, vs. 1.3%, p = 0.005). The spontaneous clearance of HCV was observed in 25.4% (15/59) of patients, and ALT was the only factor associated with it (OR/CI 0.98/0.96–1.00, P = 0.02). CONCLUSIONS: Both HBV and HCV infections are prevalent among transfusion-dependent thalassemic and hemophilic patients in Taiwan. Nevertheless, seroprevalence decreased significantly and dramatically for HCV after universal blood screening and for HBV after implementation of a universal mass vaccination program. Public Library of Science 2017-06-09 /pmc/articles/PMC5466320/ /pubmed/28598970 http://dx.doi.org/10.1371/journal.pone.0178883 Text en © 2017 Jang et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article Jang, Tyng-Yuan Lin, Pei-Chin Huang, Ching-I Liao, Yu-Mei Yeh, Ming-Lun Zeng, Yu-Sheng Liang, Po-Cheng Hsu, Wan-Yi Tsai, Shih-Pien Lin, Zu-Yau Chen, Shinn-Cherng Huang, Jee-Fu Dai, Chia-Yen Huang, Chung-Feng Chiou, Shyh-Shin Chuang, Wan-Long Yu, Ming-Lung Seroprevalence and clinical characteristics of viral hepatitis in transfusion-dependent thalassemia and hemophilia patients |
title | Seroprevalence and clinical characteristics of viral hepatitis in transfusion-dependent thalassemia and hemophilia patients |
title_full | Seroprevalence and clinical characteristics of viral hepatitis in transfusion-dependent thalassemia and hemophilia patients |
title_fullStr | Seroprevalence and clinical characteristics of viral hepatitis in transfusion-dependent thalassemia and hemophilia patients |
title_full_unstemmed | Seroprevalence and clinical characteristics of viral hepatitis in transfusion-dependent thalassemia and hemophilia patients |
title_short | Seroprevalence and clinical characteristics of viral hepatitis in transfusion-dependent thalassemia and hemophilia patients |
title_sort | seroprevalence and clinical characteristics of viral hepatitis in transfusion-dependent thalassemia and hemophilia patients |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5466320/ https://www.ncbi.nlm.nih.gov/pubmed/28598970 http://dx.doi.org/10.1371/journal.pone.0178883 |
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