Drosophila DNA polymerase theta utilizes both helicase-like and polymerase domains during microhomology-mediated end joining and interstrand crosslink repair

Double strand breaks (DSBs) and interstrand crosslinks (ICLs) are toxic DNA lesions that can be repaired through multiple pathways, some of which involve shared proteins. One of these proteins, DNA Polymerase θ (Pol θ), coordinates a mutagenic DSB repair pathway named microhomology-mediated end join...

Descripción completa

Detalles Bibliográficos
Autores principales: Beagan, Kelly, Armstrong, Robin L., Witsell, Alice, Roy, Upasana, Renedo, Nikolai, Baker, Amy E., Schärer, Orlando D., McVey, Mitch
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5466332/
https://www.ncbi.nlm.nih.gov/pubmed/28542210
http://dx.doi.org/10.1371/journal.pgen.1006813

Ejemplares similares

Ejemplares similares