Silencing of both ATF4 and PERK inhibits cell cycle progression and promotes the apoptosis of differentiating chondrocytes

In the current study, we demonstrate that the silencing of protein kinase R (PKR)-like endoplasmic reticulum (ER) kinase (PERK) and activating transcription factor 6 (ATF4) (using small interfering RNA expression constructs) inhibits the chondrocyte cell cycle and proliferation in vitro and ex vivo....

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Detalles Bibliográficos
Autores principales: Wu, Zhimeng, Li, Meiling, Zheng, Wei, Hu, Qin, Cheng, Zhi, Guo, Fengjin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2017
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5466379/
https://www.ncbi.nlm.nih.gov/pubmed/28498443
http://dx.doi.org/10.3892/ijmm.2017.2985

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5466379/
https://www.ncbi.nlm.nih.gov/pubmed/28498443
http://dx.doi.org/10.3892/ijmm.2017.2985

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