The protective effects of PCPA against monocrotaline-induced pulmonary arterial hypertension are mediated through the downregulation of NFAT-1 and NF-κB

Inflammation and remodeling play a role in the pathogenesis of pulmonary arterial hypertension (PAH). Nuclear factor-κB (NF-κB) and nuclear factor of activated T cells-1 (NFAT-1) participate in inflammation and remodeling in a number of diseases. As a tryptophan hydroxylase inhibitor, 4-chloro-DL-ph...

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Detalles Bibliográficos
Autores principales: Bai, Yang, Li, Zhong-Xia, Wang, Huai-Liang, Lian, Guo-Chao, Wang, Yun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2017
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5466386/
https://www.ncbi.nlm.nih.gov/pubmed/28560440
http://dx.doi.org/10.3892/ijmm.2017.3001

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5466386/
https://www.ncbi.nlm.nih.gov/pubmed/28560440
http://dx.doi.org/10.3892/ijmm.2017.3001

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