Collagen-derived N-acetylated proline-glycine-proline upregulates the expression of pro-inflammatory cytokines and extracellular matrix proteases in nucleus pulposus cells via the NF-κB and MAPK signaling pathways

N-acetylated proline-glycine-proline (N-Ac-PGP) is a chemokine involved in inflammatory diseases and is found to accumulate in degenerative discs. N-Ac-PGP has been demonstrated to have a pro-inflammatory effect on human cartilage endplate stem cells. However, the effect of N-Ac-PGP on human interve...

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Detalles Bibliográficos
Autores principales: Feng, Chencheng, He, Jinyue, Zhang, Yang, Lan, Minghong, Yang, Minghui, Liu, Huan, Huang, Bo, Pan, Yong, Zhou, Yue
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2017
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5466390/
https://www.ncbi.nlm.nih.gov/pubmed/28560408
http://dx.doi.org/10.3892/ijmm.2017.3005

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