Monoamine oxidase A upregulated by chronic intermittent hypoxia activates indoleamine 2,3-dioxygenase and neurodegeneration

Co-morbid depression is prevalent in patients with obstructive sleep apnea. Here we report that monoamine oxidase A (MAO-A) plays pathogenic roles in the comorbidity. We found that chronic intermittent hypoxia significantly increased the MAO-A expression in the rat hippocampus and markedly decreased...

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Detalles Bibliográficos
Autores principales: Lam, Chun-Sing, Li, Jing-Jie, Tipoe, George Lim, Youdim, Moussa B. H., Fung, Man-Lung
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5466431/
https://www.ncbi.nlm.nih.gov/pubmed/28599322
http://dx.doi.org/10.1371/journal.pone.0177940

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5466431/
https://www.ncbi.nlm.nih.gov/pubmed/28599322
http://dx.doi.org/10.1371/journal.pone.0177940

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