Nucleic Acid Polymers with Accelerated Plasma and Tissue Clearance for Chronic Hepatitis B Therapy

REP 2139 is a nucleic acid polymer (NAP) currently under clinical development for chronic hepatitis B (HBV) therapy. This preclinical study investigated different REP 2139 analogs that would display reduced accumulation in the serum and tissues, while retaining an antiviral effect against HBV infect...

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Detalles Bibliográficos
Autores principales: Roehl, Ingo, Seiffert, Stephan, Brikh, Celia, Quinet, Jonathan, Jamard, Catherine, Dorfler, Nadine, Lockridge, Jennifer A., Cova, Lucyna, Vaillant, Andrew
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2017
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5466589/
https://www.ncbi.nlm.nih.gov/pubmed/28918011
http://dx.doi.org/10.1016/j.omtn.2017.04.019

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