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Blunted amygdala functional connectivity during a stress task in alcohol dependent individuals: A pilot study

BACKGROUND: Scant research has been conducted on neural mechanisms underlying stress processing in individuals with alcohol dependence (AD). We examined neural substrates of stress in AD individuals compared with controls using an fMRI task previously shown to induce stress, assessing amygdala funct...

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Autores principales: Wade, Natasha E., Padula, Claudia B., Anthenelli, Robert M., Nelson, Erik, Eliassen, James, Lisdahl, Krista M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5466595/
https://www.ncbi.nlm.nih.gov/pubmed/28626785
http://dx.doi.org/10.1016/j.ynstr.2017.05.004
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author Wade, Natasha E.
Padula, Claudia B.
Anthenelli, Robert M.
Nelson, Erik
Eliassen, James
Lisdahl, Krista M.
author_facet Wade, Natasha E.
Padula, Claudia B.
Anthenelli, Robert M.
Nelson, Erik
Eliassen, James
Lisdahl, Krista M.
author_sort Wade, Natasha E.
collection PubMed
description BACKGROUND: Scant research has been conducted on neural mechanisms underlying stress processing in individuals with alcohol dependence (AD). We examined neural substrates of stress in AD individuals compared with controls using an fMRI task previously shown to induce stress, assessing amygdala functional connectivity to medial prefrontal cortex (mPFC). MATERIALS AND METHODS: For this novel pilot study, 10 abstinent AD individuals and 11 controls completed a modified Trier stress task while undergoing fMRI acquisition. The amygdala was used as a seed region for whole-brain seed-based functional connectivity analysis. RESULTS: After controlling for family-wise error (p = 0.05), there was significantly decreased left and right amygdala connectivity with frontal (specifically mPFC), temporal, parietal, and cerebellar regions. Subjective stress, but not craving, increased from pre-to post-task. CONCLUSIONS: This study demonstrated decreased connectivity between the amygdala and regions important for stress and emotional processing in long-term abstinent individuals with AD. These results suggest aberrant stress processing in individuals with AD even after lengthy periods of abstinence.
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spelling pubmed-54665952017-06-16 Blunted amygdala functional connectivity during a stress task in alcohol dependent individuals: A pilot study Wade, Natasha E. Padula, Claudia B. Anthenelli, Robert M. Nelson, Erik Eliassen, James Lisdahl, Krista M. Neurobiol Stress Original Research Article BACKGROUND: Scant research has been conducted on neural mechanisms underlying stress processing in individuals with alcohol dependence (AD). We examined neural substrates of stress in AD individuals compared with controls using an fMRI task previously shown to induce stress, assessing amygdala functional connectivity to medial prefrontal cortex (mPFC). MATERIALS AND METHODS: For this novel pilot study, 10 abstinent AD individuals and 11 controls completed a modified Trier stress task while undergoing fMRI acquisition. The amygdala was used as a seed region for whole-brain seed-based functional connectivity analysis. RESULTS: After controlling for family-wise error (p = 0.05), there was significantly decreased left and right amygdala connectivity with frontal (specifically mPFC), temporal, parietal, and cerebellar regions. Subjective stress, but not craving, increased from pre-to post-task. CONCLUSIONS: This study demonstrated decreased connectivity between the amygdala and regions important for stress and emotional processing in long-term abstinent individuals with AD. These results suggest aberrant stress processing in individuals with AD even after lengthy periods of abstinence. Elsevier 2017-05-31 /pmc/articles/PMC5466595/ /pubmed/28626785 http://dx.doi.org/10.1016/j.ynstr.2017.05.004 Text en © 2017 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Original Research Article
Wade, Natasha E.
Padula, Claudia B.
Anthenelli, Robert M.
Nelson, Erik
Eliassen, James
Lisdahl, Krista M.
Blunted amygdala functional connectivity during a stress task in alcohol dependent individuals: A pilot study
title Blunted amygdala functional connectivity during a stress task in alcohol dependent individuals: A pilot study
title_full Blunted amygdala functional connectivity during a stress task in alcohol dependent individuals: A pilot study
title_fullStr Blunted amygdala functional connectivity during a stress task in alcohol dependent individuals: A pilot study
title_full_unstemmed Blunted amygdala functional connectivity during a stress task in alcohol dependent individuals: A pilot study
title_short Blunted amygdala functional connectivity during a stress task in alcohol dependent individuals: A pilot study
title_sort blunted amygdala functional connectivity during a stress task in alcohol dependent individuals: a pilot study
topic Original Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5466595/
https://www.ncbi.nlm.nih.gov/pubmed/28626785
http://dx.doi.org/10.1016/j.ynstr.2017.05.004
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