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Malnutrition-sarcopenia syndrome predicts mortality in hospitalized older patients

A new term, malnutrition-sarcopenia syndrome (MSS), was recently coined to describe the clinical presentation of both malnutrition and sarcopenia. The aim of this study was to investigate the association between MSS and long-term mortality in older inpatients. We conducted a prospective study in acu...

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Autores principales: Hu, Xiaoyi, Zhang, Lei, Wang, Haozhong, Hao, Qiukui, Dong, Birong, Yang, Ming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5466644/
https://www.ncbi.nlm.nih.gov/pubmed/28600505
http://dx.doi.org/10.1038/s41598-017-03388-3
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author Hu, Xiaoyi
Zhang, Lei
Wang, Haozhong
Hao, Qiukui
Dong, Birong
Yang, Ming
author_facet Hu, Xiaoyi
Zhang, Lei
Wang, Haozhong
Hao, Qiukui
Dong, Birong
Yang, Ming
author_sort Hu, Xiaoyi
collection PubMed
description A new term, malnutrition-sarcopenia syndrome (MSS), was recently coined to describe the clinical presentation of both malnutrition and sarcopenia. The aim of this study was to investigate the association between MSS and long-term mortality in older inpatients. We conducted a prospective study in acute geriatric wards of two local hospitals in China. Muscle mass and malnutrition were estimated by anthropometric measures and the Mini Nutritional Assessment (MNA). Of the 453 participants, 14 (3.1%) had sarcopenia with normal nutrition, 139 (30.7%) had malnutrition risk without sarcopenia, 48 (10.6%) had malnutrition risk with sarcopenia, 25 (5.5%) had malnutrition without sarcopenia, and 22 (4.9%) had MSS at baseline. Compared with non-sarcopenic subjects with normal nutrition, subjects with MSS and subjects with malnutrition risk and sarcopenia were more than four times more likely to die (hazard ratio [HR], 4.78; 95% confidence interval [CI], 2.09–10.97; and HR, 4.25; 95% CI, 2.22–8.12, respectively); non-sarcopenic subjects with malnutrition risk were more than two times more likely to die (HR, 2.41; 95% CI, 1.32–4.39). In conclusion, MSS may serve as a prognostic factor in the management of hospitalized older patients.
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spelling pubmed-54666442017-06-14 Malnutrition-sarcopenia syndrome predicts mortality in hospitalized older patients Hu, Xiaoyi Zhang, Lei Wang, Haozhong Hao, Qiukui Dong, Birong Yang, Ming Sci Rep Article A new term, malnutrition-sarcopenia syndrome (MSS), was recently coined to describe the clinical presentation of both malnutrition and sarcopenia. The aim of this study was to investigate the association between MSS and long-term mortality in older inpatients. We conducted a prospective study in acute geriatric wards of two local hospitals in China. Muscle mass and malnutrition were estimated by anthropometric measures and the Mini Nutritional Assessment (MNA). Of the 453 participants, 14 (3.1%) had sarcopenia with normal nutrition, 139 (30.7%) had malnutrition risk without sarcopenia, 48 (10.6%) had malnutrition risk with sarcopenia, 25 (5.5%) had malnutrition without sarcopenia, and 22 (4.9%) had MSS at baseline. Compared with non-sarcopenic subjects with normal nutrition, subjects with MSS and subjects with malnutrition risk and sarcopenia were more than four times more likely to die (hazard ratio [HR], 4.78; 95% confidence interval [CI], 2.09–10.97; and HR, 4.25; 95% CI, 2.22–8.12, respectively); non-sarcopenic subjects with malnutrition risk were more than two times more likely to die (HR, 2.41; 95% CI, 1.32–4.39). In conclusion, MSS may serve as a prognostic factor in the management of hospitalized older patients. Nature Publishing Group UK 2017-06-09 /pmc/articles/PMC5466644/ /pubmed/28600505 http://dx.doi.org/10.1038/s41598-017-03388-3 Text en © The Author(s) 2017 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Hu, Xiaoyi
Zhang, Lei
Wang, Haozhong
Hao, Qiukui
Dong, Birong
Yang, Ming
Malnutrition-sarcopenia syndrome predicts mortality in hospitalized older patients
title Malnutrition-sarcopenia syndrome predicts mortality in hospitalized older patients
title_full Malnutrition-sarcopenia syndrome predicts mortality in hospitalized older patients
title_fullStr Malnutrition-sarcopenia syndrome predicts mortality in hospitalized older patients
title_full_unstemmed Malnutrition-sarcopenia syndrome predicts mortality in hospitalized older patients
title_short Malnutrition-sarcopenia syndrome predicts mortality in hospitalized older patients
title_sort malnutrition-sarcopenia syndrome predicts mortality in hospitalized older patients
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5466644/
https://www.ncbi.nlm.nih.gov/pubmed/28600505
http://dx.doi.org/10.1038/s41598-017-03388-3
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