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Serum Lipid Levels and Risk Of Hand Osteoarthritis: The Chingford Prospective Cohort Study

The development of hand osteoarthritis (HOA) could be linked to hyperlipidaemia. No longitudinal studies have addressed the relationship between serum lipid profile and HOA. The study aim was to determine the association between serum lipid profile and the incidence of radiographic hand osteoarthrit...

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Autores principales: Garcia-Gil, M., Reyes, C., Ramos, R., Sanchez-Santos, M. T., Prieto-Alhambra, D., Spector, T. D., Hart, D. J., Arden, N. K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5466681/
https://www.ncbi.nlm.nih.gov/pubmed/28600494
http://dx.doi.org/10.1038/s41598-017-03317-4
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author Garcia-Gil, M.
Reyes, C.
Ramos, R.
Sanchez-Santos, M. T.
Prieto-Alhambra, D.
Spector, T. D.
Hart, D. J.
Arden, N. K.
author_facet Garcia-Gil, M.
Reyes, C.
Ramos, R.
Sanchez-Santos, M. T.
Prieto-Alhambra, D.
Spector, T. D.
Hart, D. J.
Arden, N. K.
author_sort Garcia-Gil, M.
collection PubMed
description The development of hand osteoarthritis (HOA) could be linked to hyperlipidaemia. No longitudinal studies have addressed the relationship between serum lipid profile and HOA. The study aim was to determine the association between serum lipid profile and the incidence of radiographic hand osteoarthritis (RHOA). All women in a prospective population-based cohort from the Chingford study with available baseline lipid measurements and without RHOA on a baseline were included. Study outcome was the incidence of RHOA in year 11 of follow-up. Serum lipid profile variables were analysed as continuous variables and categorised into quartiles. The association between serum lipid profile and RHOA was modeled using multivariable logistic regression. Overall RHOA incidence was 51.6% (45.7–57.4%). An inverse association between HDL cholesterol levels and the incidence of RHOA was observed by quartile: OR of 0.36 [95%CI 0.17–0.75], 0.52 [95%CI 0.26–1.06], and 0.48 [95%CI 0.22–1.03]. Triglycerides levels showed a significant trend. No relationship was found with total or LDL cholesterol. Higher levels of HDL cholesterol appear to protect against RHOA after 11 years of follow-up. More research is needed to elucidate HOA risk factors, the mechanisms related to the lipid pathway, and the effects of lipid-lowering agents on reducing the incidence of OA.
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spelling pubmed-54666812017-06-14 Serum Lipid Levels and Risk Of Hand Osteoarthritis: The Chingford Prospective Cohort Study Garcia-Gil, M. Reyes, C. Ramos, R. Sanchez-Santos, M. T. Prieto-Alhambra, D. Spector, T. D. Hart, D. J. Arden, N. K. Sci Rep Article The development of hand osteoarthritis (HOA) could be linked to hyperlipidaemia. No longitudinal studies have addressed the relationship between serum lipid profile and HOA. The study aim was to determine the association between serum lipid profile and the incidence of radiographic hand osteoarthritis (RHOA). All women in a prospective population-based cohort from the Chingford study with available baseline lipid measurements and without RHOA on a baseline were included. Study outcome was the incidence of RHOA in year 11 of follow-up. Serum lipid profile variables were analysed as continuous variables and categorised into quartiles. The association between serum lipid profile and RHOA was modeled using multivariable logistic regression. Overall RHOA incidence was 51.6% (45.7–57.4%). An inverse association between HDL cholesterol levels and the incidence of RHOA was observed by quartile: OR of 0.36 [95%CI 0.17–0.75], 0.52 [95%CI 0.26–1.06], and 0.48 [95%CI 0.22–1.03]. Triglycerides levels showed a significant trend. No relationship was found with total or LDL cholesterol. Higher levels of HDL cholesterol appear to protect against RHOA after 11 years of follow-up. More research is needed to elucidate HOA risk factors, the mechanisms related to the lipid pathway, and the effects of lipid-lowering agents on reducing the incidence of OA. Nature Publishing Group UK 2017-06-09 /pmc/articles/PMC5466681/ /pubmed/28600494 http://dx.doi.org/10.1038/s41598-017-03317-4 Text en © The Author(s) 2017 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Garcia-Gil, M.
Reyes, C.
Ramos, R.
Sanchez-Santos, M. T.
Prieto-Alhambra, D.
Spector, T. D.
Hart, D. J.
Arden, N. K.
Serum Lipid Levels and Risk Of Hand Osteoarthritis: The Chingford Prospective Cohort Study
title Serum Lipid Levels and Risk Of Hand Osteoarthritis: The Chingford Prospective Cohort Study
title_full Serum Lipid Levels and Risk Of Hand Osteoarthritis: The Chingford Prospective Cohort Study
title_fullStr Serum Lipid Levels and Risk Of Hand Osteoarthritis: The Chingford Prospective Cohort Study
title_full_unstemmed Serum Lipid Levels and Risk Of Hand Osteoarthritis: The Chingford Prospective Cohort Study
title_short Serum Lipid Levels and Risk Of Hand Osteoarthritis: The Chingford Prospective Cohort Study
title_sort serum lipid levels and risk of hand osteoarthritis: the chingford prospective cohort study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5466681/
https://www.ncbi.nlm.nih.gov/pubmed/28600494
http://dx.doi.org/10.1038/s41598-017-03317-4
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