Subcutaneous Immunization with Fusion Protein DnaJ-ΔA146Ply without Additional Adjuvants Induces both Humoral and Cellular Immunity against Pneumococcal Infection Partially Depending on TLR4

Subunit vaccines that are poorly immunogenic are often combined with adjuvants for immunization. Our previous research identified a pneumolysin variant (ΔA146Ply), a Toll-like receptor 4 agonist, that was an effective adjuvant in the protection of fusion protein DnaJ-ΔA146Ply against mucosal Strepto...

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Detalles Bibliográficos
Autores principales: Su, Yufeng, Li, Dagen, Xing, Yan, Wang, Hong, Wang, Jian, Yuan, Jun, Wang, Xiaofang, Cui, Fang, Yin, Yibing, Zhang, Xuemei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2017
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5466963/
https://www.ncbi.nlm.nih.gov/pubmed/28659923
http://dx.doi.org/10.3389/fimmu.2017.00686

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5466963/
https://www.ncbi.nlm.nih.gov/pubmed/28659923
http://dx.doi.org/10.3389/fimmu.2017.00686

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