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Role of Interleukin-10 in Acute Brain Injuries

Interleukin-10 (IL-10) is an important anti-inflammatory cytokine expressed in response to brain injury, where it facilitates the resolution of inflammatory cascades, which if prolonged causes secondary brain damage. Here, we comprehensively review the current knowledge regarding the role of IL-10 i...

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Autores principales: Garcia, Joshua M., Stillings, Stephanie A., Leclerc, Jenna L., Phillips, Harrison, Edwards, Nancy J., Robicsek, Steven A., Hoh, Brian L., Blackburn, Spiros, Doré, Sylvain
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5466968/
https://www.ncbi.nlm.nih.gov/pubmed/28659854
http://dx.doi.org/10.3389/fneur.2017.00244
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author Garcia, Joshua M.
Stillings, Stephanie A.
Leclerc, Jenna L.
Phillips, Harrison
Edwards, Nancy J.
Robicsek, Steven A.
Hoh, Brian L.
Blackburn, Spiros
Doré, Sylvain
author_facet Garcia, Joshua M.
Stillings, Stephanie A.
Leclerc, Jenna L.
Phillips, Harrison
Edwards, Nancy J.
Robicsek, Steven A.
Hoh, Brian L.
Blackburn, Spiros
Doré, Sylvain
author_sort Garcia, Joshua M.
collection PubMed
description Interleukin-10 (IL-10) is an important anti-inflammatory cytokine expressed in response to brain injury, where it facilitates the resolution of inflammatory cascades, which if prolonged causes secondary brain damage. Here, we comprehensively review the current knowledge regarding the role of IL-10 in modulating outcomes following acute brain injury, including traumatic brain injury (TBI) and the various stroke subtypes. The vascular endothelium is closely tied to the pathophysiology of these neurological disorders and research has demonstrated clear vascular endothelial protective properties for IL-10. In vitro and in vivo models of ischemic stroke have convincingly directly and indirectly shown IL-10-mediated neuroprotection; although clinically, the role of IL-10 in predicting risk and outcomes is less clear. Comparatively, conclusive studies investigating the contribution of IL-10 in subarachnoid hemorrhage are lacking. Weak indirect evidence supporting the protective role of IL-10 in preclinical models of intracerebral hemorrhage exists; however, in the limited number of clinical studies, higher IL-10 levels seen post-ictus have been associated with worse outcomes. Similarly, preclinical TBI models have suggested a neuroprotective role for IL-10; although, controversy exists among the several clinical studies. In summary, while IL-10 is consistently elevated following acute brain injury, the effect of IL-10 appears to be pathology dependent, and preclinical and clinical studies often paradoxically yield opposite results. The pronounced and potent effects of IL-10 in the resolution of inflammation and inconsistency in the literature regarding the contribution of IL-10 in the setting of acute brain injury warrant further rigorously controlled and targeted investigation.
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spelling pubmed-54669682017-06-28 Role of Interleukin-10 in Acute Brain Injuries Garcia, Joshua M. Stillings, Stephanie A. Leclerc, Jenna L. Phillips, Harrison Edwards, Nancy J. Robicsek, Steven A. Hoh, Brian L. Blackburn, Spiros Doré, Sylvain Front Neurol Neuroscience Interleukin-10 (IL-10) is an important anti-inflammatory cytokine expressed in response to brain injury, where it facilitates the resolution of inflammatory cascades, which if prolonged causes secondary brain damage. Here, we comprehensively review the current knowledge regarding the role of IL-10 in modulating outcomes following acute brain injury, including traumatic brain injury (TBI) and the various stroke subtypes. The vascular endothelium is closely tied to the pathophysiology of these neurological disorders and research has demonstrated clear vascular endothelial protective properties for IL-10. In vitro and in vivo models of ischemic stroke have convincingly directly and indirectly shown IL-10-mediated neuroprotection; although clinically, the role of IL-10 in predicting risk and outcomes is less clear. Comparatively, conclusive studies investigating the contribution of IL-10 in subarachnoid hemorrhage are lacking. Weak indirect evidence supporting the protective role of IL-10 in preclinical models of intracerebral hemorrhage exists; however, in the limited number of clinical studies, higher IL-10 levels seen post-ictus have been associated with worse outcomes. Similarly, preclinical TBI models have suggested a neuroprotective role for IL-10; although, controversy exists among the several clinical studies. In summary, while IL-10 is consistently elevated following acute brain injury, the effect of IL-10 appears to be pathology dependent, and preclinical and clinical studies often paradoxically yield opposite results. The pronounced and potent effects of IL-10 in the resolution of inflammation and inconsistency in the literature regarding the contribution of IL-10 in the setting of acute brain injury warrant further rigorously controlled and targeted investigation. Frontiers Media S.A. 2017-06-12 /pmc/articles/PMC5466968/ /pubmed/28659854 http://dx.doi.org/10.3389/fneur.2017.00244 Text en Copyright © 2017 Garcia, Stillings, Leclerc, Phillips, Edwards, Robicsek, Hoh, Blackburn and Doré. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Garcia, Joshua M.
Stillings, Stephanie A.
Leclerc, Jenna L.
Phillips, Harrison
Edwards, Nancy J.
Robicsek, Steven A.
Hoh, Brian L.
Blackburn, Spiros
Doré, Sylvain
Role of Interleukin-10 in Acute Brain Injuries
title Role of Interleukin-10 in Acute Brain Injuries
title_full Role of Interleukin-10 in Acute Brain Injuries
title_fullStr Role of Interleukin-10 in Acute Brain Injuries
title_full_unstemmed Role of Interleukin-10 in Acute Brain Injuries
title_short Role of Interleukin-10 in Acute Brain Injuries
title_sort role of interleukin-10 in acute brain injuries
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5466968/
https://www.ncbi.nlm.nih.gov/pubmed/28659854
http://dx.doi.org/10.3389/fneur.2017.00244
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