Cell Polarization and Epigenetic Status Shape the Heterogeneous Response to Type III Interferons in Intestinal Epithelial Cells

Type I and type III interferons (IFNs) are crucial components of the first-line antiviral host response. While specific receptors for both IFN types exist, intracellular signaling shares the same Jak-STAT pathway. Due to its receptor expression, IFN-λ responsiveness is restricted mainly to epithelia...

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Detalles Bibliográficos
Autores principales: Bhushal, Sudeep, Wolfsmüller, Markus, Selvakumar, Tharini A., Kemper, Lucas, Wirth, Dagmar, Hornef, Mathias W., Hauser, Hansjörg, Köster, Mario
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2017
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5467006/
https://www.ncbi.nlm.nih.gov/pubmed/28659914
http://dx.doi.org/10.3389/fimmu.2017.00671

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