Acamprosate in a mouse model of fragile X syndrome: modulation of spontaneous cortical activity, ERK1/2 activation, locomotor behavior, and anxiety

BACKGROUND: Fragile X Syndrome (FXS) occurs as a result of a silenced fragile X mental retardation 1 gene (FMR1) and subsequent loss of fragile X mental retardation protein (FMRP) expression. Loss of FMRP alters excitatory/inhibitory signaling balance, leading to increased neuronal hyperexcitability...

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Detalles Bibliográficos
Autores principales: Schaefer, Tori L., Davenport, Matthew H., Grainger, Lindsay M., Robinson, Chandler K., Earnheart, Anthony T., Stegman, Melinda S., Lang, Anna L., Ashworth, Amy A., Molinaro, Gemma, Huber, Kimberly M., Erickson, Craig A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5467053/
https://www.ncbi.nlm.nih.gov/pubmed/28616095
http://dx.doi.org/10.1186/s11689-017-9184-y

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