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Bioactive Antimicrobial Peptides as Therapeutics for Corneal Wounds and Infections

Significance: More than 2 million eye injuries and infections occur each year in the United States that leave civilians and military members with reduced or complete vision loss due to the lack of effective therapeutics. Severe ocular injuries and infections occur in varied settings including the ho...

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Autores principales: Griffith, Gina L., Kasus-Jacobi, Anne, Pereira, H. Anne
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Mary Ann Liebert, Inc. 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5467138/
https://www.ncbi.nlm.nih.gov/pubmed/28616359
http://dx.doi.org/10.1089/wound.2016.0713
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author Griffith, Gina L.
Kasus-Jacobi, Anne
Pereira, H. Anne
author_facet Griffith, Gina L.
Kasus-Jacobi, Anne
Pereira, H. Anne
author_sort Griffith, Gina L.
collection PubMed
description Significance: More than 2 million eye injuries and infections occur each year in the United States that leave civilians and military members with reduced or complete vision loss due to the lack of effective therapeutics. Severe ocular injuries and infections occur in varied settings including the home, workplace, and battlefields. In this review, we discuss the potential of developing antimicrobial peptides (AMPs) as therapeutics for the treatment of corneal wounds and infections for which the current treatment options are inadequate. Recent Advances: Standard-of-care employs the use of fluorescein dye for the diagnosis of ocular defects and is followed by the use of antibiotics and/or steroids to treat the infection and reduce inflammation. Recent advances for treating corneal wounds include the development of amniotic membrane therapies, wound chambers, and drug-loaded hydrogels. In this review, we will discuss an innovative approach using AMPs with the dual effect of promoting corneal wound healing and clearing infections. Critical Issues: An important aspect of treating ocular injuries is that treatments need to be effective and administered expeditiously. This is especially important for injuries that occur during combat and in individuals who demonstrate delayed wound healing. To overcome gaps in current treatment modalities, bioactive peptides based on naturally occurring cationic antimicrobial proteins are being investigated as new therapeutics. Future Directions: The development of new therapeutics that can treat ocular infections and promote corneal wound healing, including the healing of persistent corneal epithelial defects, would be of great clinical benefit.
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spelling pubmed-54671382017-06-14 Bioactive Antimicrobial Peptides as Therapeutics for Corneal Wounds and Infections Griffith, Gina L. Kasus-Jacobi, Anne Pereira, H. Anne Adv Wound Care (New Rochelle) Issue Editor: Jaideep BanerjeeComprehensive Invited Reviews Significance: More than 2 million eye injuries and infections occur each year in the United States that leave civilians and military members with reduced or complete vision loss due to the lack of effective therapeutics. Severe ocular injuries and infections occur in varied settings including the home, workplace, and battlefields. In this review, we discuss the potential of developing antimicrobial peptides (AMPs) as therapeutics for the treatment of corneal wounds and infections for which the current treatment options are inadequate. Recent Advances: Standard-of-care employs the use of fluorescein dye for the diagnosis of ocular defects and is followed by the use of antibiotics and/or steroids to treat the infection and reduce inflammation. Recent advances for treating corneal wounds include the development of amniotic membrane therapies, wound chambers, and drug-loaded hydrogels. In this review, we will discuss an innovative approach using AMPs with the dual effect of promoting corneal wound healing and clearing infections. Critical Issues: An important aspect of treating ocular injuries is that treatments need to be effective and administered expeditiously. This is especially important for injuries that occur during combat and in individuals who demonstrate delayed wound healing. To overcome gaps in current treatment modalities, bioactive peptides based on naturally occurring cationic antimicrobial proteins are being investigated as new therapeutics. Future Directions: The development of new therapeutics that can treat ocular infections and promote corneal wound healing, including the healing of persistent corneal epithelial defects, would be of great clinical benefit. Mary Ann Liebert, Inc. 2017-06-01 2017-06-01 /pmc/articles/PMC5467138/ /pubmed/28616359 http://dx.doi.org/10.1089/wound.2016.0713 Text en © Gina L. Griffith et al., 2017; Published by Mary Ann Liebert, Inc. This article is available under the Creative Commons License CC-BY-NC (http://creativecommons.org/licenses/by-nc/4.0). This license permits non-commercial use, distribution and reproduction in any medium, provided the original work is properly cited. Permission only needs to be obtained for commercial use and can be done via RightsLink.
spellingShingle Issue Editor: Jaideep BanerjeeComprehensive Invited Reviews
Griffith, Gina L.
Kasus-Jacobi, Anne
Pereira, H. Anne
Bioactive Antimicrobial Peptides as Therapeutics for Corneal Wounds and Infections
title Bioactive Antimicrobial Peptides as Therapeutics for Corneal Wounds and Infections
title_full Bioactive Antimicrobial Peptides as Therapeutics for Corneal Wounds and Infections
title_fullStr Bioactive Antimicrobial Peptides as Therapeutics for Corneal Wounds and Infections
title_full_unstemmed Bioactive Antimicrobial Peptides as Therapeutics for Corneal Wounds and Infections
title_short Bioactive Antimicrobial Peptides as Therapeutics for Corneal Wounds and Infections
title_sort bioactive antimicrobial peptides as therapeutics for corneal wounds and infections
topic Issue Editor: Jaideep BanerjeeComprehensive Invited Reviews
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5467138/
https://www.ncbi.nlm.nih.gov/pubmed/28616359
http://dx.doi.org/10.1089/wound.2016.0713
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