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Practical High-Throughput Experimentation for Chemists
[Image: see text] Large arrays of hypothesis-driven, rationally designed experiments are powerful tools for solving complex chemical problems. Conceptual and practical aspects of chemical high-throughput experimentation are discussed. A case study in the application of high-throughput experimentatio...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Chemical
Society
2017
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5467193/ https://www.ncbi.nlm.nih.gov/pubmed/28626518 http://dx.doi.org/10.1021/acsmedchemlett.7b00165 |
| _version_ | 1783243222458302464 |
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| author | Shevlin, Michael |
| author_facet | Shevlin, Michael |
| author_sort | Shevlin, Michael |
| collection | PubMed |
| description | [Image: see text] Large arrays of hypothesis-driven, rationally designed experiments are powerful tools for solving complex chemical problems. Conceptual and practical aspects of chemical high-throughput experimentation are discussed. A case study in the application of high-throughput experimentation to a key synthetic step in a drug discovery program and subsequent optimization for the first large scale synthesis of a drug candidate is exemplified. |
| format | Online Article Text |
| id | pubmed-5467193 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2017 |
| publisher | American Chemical
Society |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-54671932017-06-16 Practical High-Throughput Experimentation for Chemists Shevlin, Michael ACS Med Chem Lett [Image: see text] Large arrays of hypothesis-driven, rationally designed experiments are powerful tools for solving complex chemical problems. Conceptual and practical aspects of chemical high-throughput experimentation are discussed. A case study in the application of high-throughput experimentation to a key synthetic step in a drug discovery program and subsequent optimization for the first large scale synthesis of a drug candidate is exemplified. American Chemical Society 2017-05-17 /pmc/articles/PMC5467193/ /pubmed/28626518 http://dx.doi.org/10.1021/acsmedchemlett.7b00165 Text en Copyright © 2017 American Chemical Society This is an open access article published under an ACS AuthorChoice License (http://pubs.acs.org/page/policy/authorchoice_termsofuse.html) , which permits copying and redistribution of the article or any adaptations for non-commercial purposes. |
| spellingShingle | Shevlin, Michael Practical High-Throughput Experimentation for Chemists |
| title | Practical High-Throughput Experimentation for Chemists |
| title_full | Practical High-Throughput Experimentation for Chemists |
| title_fullStr | Practical High-Throughput Experimentation for Chemists |
| title_full_unstemmed | Practical High-Throughput Experimentation for Chemists |
| title_short | Practical High-Throughput Experimentation for Chemists |
| title_sort | practical high-throughput experimentation for chemists |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5467193/ https://www.ncbi.nlm.nih.gov/pubmed/28626518 http://dx.doi.org/10.1021/acsmedchemlett.7b00165 |
| work_keys_str_mv | AT shevlinmichael practicalhighthroughputexperimentationforchemists |