Loss of Parkinson's disease-associated protein CHCHD2 affects mitochondrial crista structure and destabilizes cytochrome c

Mutations in CHCHD2 have been identified in some Parkinson's disease (PD) cases. To understand the physiological and pathological roles of CHCHD2, we manipulated the expression of CHCHD2 in Drosophila and mammalian cells. The loss of CHCHD2 in Drosophila causes abnormal matrix structures and im...

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Detalles Bibliográficos
Autores principales: Meng, Hongrui, Yamashita, Chikara, Shiba-Fukushima, Kahori, Inoshita, Tsuyoshi, Funayama, Manabu, Sato, Shigeto, Hatta, Tomohisa, Natsume, Tohru, Umitsu, Masataka, Takagi, Junichi, Imai, Yuzuru, Hattori, Nobutaka
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5467237/
https://www.ncbi.nlm.nih.gov/pubmed/28589937
http://dx.doi.org/10.1038/ncomms15500

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5467237/
https://www.ncbi.nlm.nih.gov/pubmed/28589937
http://dx.doi.org/10.1038/ncomms15500

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