Misfolded polypeptides are selectively recognized and transported toward aggresomes by a CED complex

Misfolded polypeptides are rapidly cleared from cells via the ubiquitin–proteasome system (UPS). However, when the UPS is impaired, misfolded polypeptides form small cytoplasmic aggregates, which are sequestered into an aggresome and ultimately degraded by aggrephagy. Despite the relevance of the ag...

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Detalles Bibliográficos
Autores principales: Park, Joori, Park, Yeonkyoung, Ryu, Incheol, Choi, Mi-Hyun, Lee, Hyo Jin, Oh, Nara, Kim, Kyutae, Kim, Kyoung Mi, Choe, Junho, Lee, Cheolju, Baik, Ja-Hyun, Kim, Yoon Ki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5467238/
https://www.ncbi.nlm.nih.gov/pubmed/28589942
http://dx.doi.org/10.1038/ncomms15730

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