WASH maintains NKp46(+) ILC3 cells by promoting AHR expression

Innate lymphoid cells (ILCs) communicate with other haematopoietic and non-haematopoietic cells to regulate immunity, inflammation and tissue homeostasis. How these ILC lineages develop and are maintained is not clear. Here we show that WASH is highly expressed in the nucleus of group 3 ILCs (ILC3s)...

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Autores principales: Xia, Pengyan, Liu, Jing, Wang, Shuo, Ye, Buqing, Du, Ying, Xiong, Zhen, Han, Ze-Guang, Tong, Liang, Fan, Zusen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5467242/
https://www.ncbi.nlm.nih.gov/pubmed/28589939
http://dx.doi.org/10.1038/ncomms15685
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author Xia, Pengyan
Liu, Jing
Wang, Shuo
Ye, Buqing
Du, Ying
Xiong, Zhen
Han, Ze-Guang
Tong, Liang
Fan, Zusen
author_facet Xia, Pengyan
Liu, Jing
Wang, Shuo
Ye, Buqing
Du, Ying
Xiong, Zhen
Han, Ze-Guang
Tong, Liang
Fan, Zusen
author_sort Xia, Pengyan
collection PubMed
description Innate lymphoid cells (ILCs) communicate with other haematopoietic and non-haematopoietic cells to regulate immunity, inflammation and tissue homeostasis. How these ILC lineages develop and are maintained is not clear. Here we show that WASH is highly expressed in the nucleus of group 3 ILCs (ILC3s). WASH deletion impairs the cell pool of NKp46(+) ILC3s. In NKp46(+) ILC3s, WASH recruits Arid1a to the Ahr promoter thus activating AHR expression. WASH deletion in ILC3s decreases the number of NKp46(+) ILC3s. Moreover, Arid1a deletion impedes AHR expression and impairs the maintenance of NKp46(+) ILC3s. Therefore, WASH-mediated AHR expression has a critical function in the maintenance of NKp46(+) ILC3s.
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spelling pubmed-54672422017-06-19 WASH maintains NKp46(+) ILC3 cells by promoting AHR expression Xia, Pengyan Liu, Jing Wang, Shuo Ye, Buqing Du, Ying Xiong, Zhen Han, Ze-Guang Tong, Liang Fan, Zusen Nat Commun Article Innate lymphoid cells (ILCs) communicate with other haematopoietic and non-haematopoietic cells to regulate immunity, inflammation and tissue homeostasis. How these ILC lineages develop and are maintained is not clear. Here we show that WASH is highly expressed in the nucleus of group 3 ILCs (ILC3s). WASH deletion impairs the cell pool of NKp46(+) ILC3s. In NKp46(+) ILC3s, WASH recruits Arid1a to the Ahr promoter thus activating AHR expression. WASH deletion in ILC3s decreases the number of NKp46(+) ILC3s. Moreover, Arid1a deletion impedes AHR expression and impairs the maintenance of NKp46(+) ILC3s. Therefore, WASH-mediated AHR expression has a critical function in the maintenance of NKp46(+) ILC3s. Nature Publishing Group 2017-06-07 /pmc/articles/PMC5467242/ /pubmed/28589939 http://dx.doi.org/10.1038/ncomms15685 Text en Copyright © 2017, The Author(s) http://creativecommons.org/licenses/by/4.0/ Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
spellingShingle Article
Xia, Pengyan
Liu, Jing
Wang, Shuo
Ye, Buqing
Du, Ying
Xiong, Zhen
Han, Ze-Guang
Tong, Liang
Fan, Zusen
WASH maintains NKp46(+) ILC3 cells by promoting AHR expression
title WASH maintains NKp46(+) ILC3 cells by promoting AHR expression
title_full WASH maintains NKp46(+) ILC3 cells by promoting AHR expression
title_fullStr WASH maintains NKp46(+) ILC3 cells by promoting AHR expression
title_full_unstemmed WASH maintains NKp46(+) ILC3 cells by promoting AHR expression
title_short WASH maintains NKp46(+) ILC3 cells by promoting AHR expression
title_sort wash maintains nkp46(+) ilc3 cells by promoting ahr expression
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5467242/
https://www.ncbi.nlm.nih.gov/pubmed/28589939
http://dx.doi.org/10.1038/ncomms15685
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